复方灵芝孢子精油软胶囊抗疲劳增强免疫功能的研究.pdfVIP

复方灵芝孢子精油软胶囊抗疲劳增强免疫功能研究 鲍蕾蕾，陈海飞，卞俊，唐大海 （解放军第411 医院药学科，上海 200434 ） 摘要：目的 研究复方灵芝孢子精油软胶囊抗疲劳、增强免疫力的药理作用。方法 昆明种小 鼠随机分为5组，分别为复方灵芝孢子精油软胶囊（FFLZB）低、中、高(385、770、1540 mg·Kg-1)3 个剂量组、对照药红参醇提物组、空白对照组，灌胃给药 14 天后考察各组小鼠爬杆时间及 爬杆后血清肌酸激酶（CK酶）、三磷酸腺苷（ATP）含量，同时采用免疫脏器指数法、碳粒 廓清法、足趾增厚法测定迟发型变态反应（DTH），考察 FFLZB 对小鼠免疫功能的影响。结 果 FFLZB（385、770、1540 mg·Kg-1 ）3个剂量组能不同程度的延长小鼠爬杆时间，770、 -1 -1 1540 mg·Kg 两剂量组能显著提高小鼠爬杆后血清ATP水平，仅385 mg·Kg 剂量组能使爬 杆后小鼠血清 CK 酶水平显著提高，同时相比空白对照组 FFLZB 3 个剂量组能不同程度的抑 制小鼠免疫器官脏器指数的下降、提高碳粒廓清指数水平及 24、48 小时迟发型变态反应程 度。结论 复方灵芝孢子精油软胶囊具有抗疲劳及增强免疫力作用，是一种有效的抗疲劳复 方中药制剂。 关键词 抗疲劳；免疫功能；灵芝孢子精油 The Effect of Compound ganoderma lucidum spore oil soft capsule on Antifatigue Property and immunopotentiation in Mice 1 2 1 1 3 Bao Lei-lei , Yang Fan , Chen Hai-fei , Bian Jun , Tang Da-hai (Dept.of Pharmacy, NO.411 Hospital of PLA ，Shanghai 200434，China;Bai Shiqiao Qingnian Lake Cadre’s Sanitarium of General Political Department,Beijing 100011,China;Dept.of Clinical laboratory, NO.411 Hospital of PLA ，Shanghai 200434，China) ABSTRACT: AIM TO demonstrate the antifatigue effect and immunopotentiation function of Compound ganoderma lucidum spore oil soft capsule in mice. METHOD KM mice were -1 -1 radomly devided to five groups: the low, middle, and high groups(385, 770, 1540 mg·Kg ·d ), control group, positive group. After 14 days, the antifatigue effect of Compound ganoderma lucidum spore oil soft capsule(FFLZB) was investigated in a pole-jump test model of mice and detected the serum creatinine kinase (CK), adenosine triphosphate (ATP) after jump. Moreover, mice thymus and sple