2Hz和100Hz刺激在诱导大鼠视皮层长持续长时程增强中的不同作用.pdfVIP

Pan Bin et al: Different effects of tetanus on long-lasting LTP 451 Acta Physiologica Sinica, August 25, 2004, 56 (4): 451-454 Research Paper Different effects of 2 and 100 Hz tetanus on the expression of long- lasting long-term potentiation in rat visual cortical slices PAN Bin, YANG Dong-Wei, HAN Tai-Zhen* Department of Physiology, School of Medicine, Xi ’an Jiaotong University, Xi’an, Shaanxi 710061, China Abstract: Long-term potentiation (LTP) can be induced by various tetanic parameters in the mammalian visual cortex. However, little researches have been done on the relationship between the expression of the long-lasting LTP (late phase LTP or L-LTP) lasting more than 3 h and the tetanic parameters. In the present study, the effects of 2 Hz and 100 Hz tetanic parameters on L-LTP of the field potentials were recorded from the layer / of the rat visual cortical slices in response to stimulation of the layer . As a result, tetanic parameters that had more than 300 pulses reliably induced L-LTP in the postnatal day 15~21 rats. Obviously different L-LTP expressions were induced by 2 Hz and 100 Hz tetani. There was no difference in L-LTP expression induced by the parameters with the same frequency and different total pulses. These data suggest that L-LTPs induced by different frequency parameters may have different induction and maintenance mechanisms; L-LTPs induced by the parameters with the same frequency may have the same mechanisms. Key words: long-term potentiation; visual cortex 2 Hz 100 Hz * , 710061 : , (long-term potentiation, LTP) 3 h LTP (long lasting LTP, L-LTP) 3