2010,雌二醇对大鼠心肌缺血_再灌注损伤影响.pdfVIP

20 10 12 36 24 J iang su M ed J, D ecember 20 10, V ol 36, N o . 24 2935 唐成和 吴 芹 李向荣 郝 玲 田 郡 钱春野 徐红涛 ! ( IR) SD 50 , 5 : ( C ) , ( A ) 17( A L A M A H ) A A L AM A H 4 IR , 30 min 120 min A , , A A L ( L V DEP) ( M DA) ( T N F) ( T nT ) , ( L V SP) ∀ dp dtmax ( SO D) B 2 Bcl X ( Bcl2 Bax ) ; A M A H ( P 0 05) , IR ! ; ; ; ! R33 1 ! A ! 2010) Eff ects of estrogen on myocardial ischemicreperfusion injury in rats TAN G Chenghe , WU Qin , LI X ia ngr ong , et al . Depar tment o f Physio lo gy , Ya ncheng Hea lt h Vo ca tional and Technical Co llege , Yancheng 224005, CHI NA Abstract! Obj ective T o ex plor e t he eff ects of est rog en on hemo dy nam ics and cardiom yocy tes apo pto sis in rat hearts subj ect ed to ischemicr eperfu sio n ( IR) inj ury. Methods Fift y f emale SD rat s w er e rando mly div ided into 5 g roup s w ith 10 rat s each . G roup C w as sham operated . O var iect omized rats w ere treated w ith placebo ( g ro up A ) or three diff er ent doses of 17 estr adiol r eplacement ( gr oup AL , A M and AH ) fo r four w eeks, fo llo w ed by IR in vivo( ischemia fo r 30 min and reperfu sion fo r 120 min) . Hemodynamic parameter s and car diomy ocytes apoptosis w ere measured at the end of ischemia and reperfu sion . Results Body w eig ht w as dramatically increased w ith metrat rophia and reduction of ser um estr og en in g roup A . In gr oups o f A and AL , L VD EP , M DA and T NF pro ductio n, T nT release and the area o f myocar dial inf ar ct w ere all signif icantly incr eased , w hereas L VSP , ∀ dp dtmax , SO D activ ity and ratio of Bcl2 Bax w ere decreased , all of w hich w ere rever sed in g ro ups o f A M