液质联用技术在兽药多类别、多组分残留分析中应用研究进展.pdfVIP

综述与专论 液质联用技术在兽药多类别、多组分残留分析中的 应用研究进展 11 曲斌 ，耿士伟，贡玉清，姜加华，陆桂萍，蒋天梅 （江苏省畜产品质量检验测试中心，南京 210036 ） [摘 要]兽药残留分析是食品安全实验室最广泛开展的分析项目之一，液质联用技术已成为兽药残留分析的关键技术和 研究手段。除了进行少数目标组分的定量测定外，多类别、多组分的同时同步分析成为近年来兽药残留分析的发展趋势。液 相色谱串联三级四极杆质谱和液相色谱串联高分辨率质谱在兽药多残留分析中各有其特点和优势，各国研究者在牛奶、动物 组织等动物源性食品中开展了抗生素、驱虫药等多残留的检测研究与应用工作。本文就目前液质联用技术及其在兽药多残留 分析中的应用做一综述。 [关键词]液质联用；兽药残留；多残留分析；综述 State-of-the-art LC-MS in the applications of veterinary drugs multi-class， multi-residues analysis QU Bin，GENG Shiwei，GONG Yuqing，JIANG Jiahua ，LU Guiping，JIANG Tianmei （Jiangsu Quality Inspection and Testing Center for Animal Products ，Nanjing 210036 ） Abstract ：Veterinary drug residue analysis （VDRA ） is one of the most widely studied subjects in analytical laboratories working in the field of food safety. LC-MS is nowadays the main technique of choice for VDRA. Except of the quantitative determination of several target compounds，the trend of VDRA is mainly simultaneous analysis of multi-class multi-residuals based on MS screening method in a single analysis. Liquid chromatography tandem triple quadrupole MS （LC-QqQ MS ） and liquid chromatography tandem high resolution MS （LC-HRMS ） have many characteristics and advantages ，respectively. LC-MS multi-residue methods have been developed and applied to detect such as antibiotics ，anthelmintics in animal-derived foods. This paper is focused on the progress of the current LC-MS methods applied to the cutting-edge applications on veterinary multi-residue analysis. Key words：LC-MS ；veterinary drug residue ；multi-residue analysis ；review 1 引言 兽药是具有不同化学结构和动物治疗作用的药物，兽药的使用会造成兽药原药、或其代谢物在动物源 性食品中的残留[1]