泌尿系感染病原菌耐药性与经验用药的调查分析.docVIP

泌尿系感染病原菌耐药性与经验用药的调查分析 【摘要】 目的 泌尿感染病原菌分布耐药临床方法 2012年月至20年月泌尿感染病原。结果病原其中革兰阴性菌株,68.4%；革兰阳性菌株24.6%；真菌株％大肠埃希菌革兰阴性杆菌对亚胺培南、头孢哌酮/舒巴坦哌拉西林/他唑巴坦以及耐药率革兰阳性球菌对利奈唑胺、万古霉素、替考拉宁经验用药与药敏试验结果的符合率为.9%。结论 尿感染病原菌耐药抗菌药物 【关键词】 泌尿系感染; 病原菌; 耐药性Analysis on drug resistance of pathogens and experienced medication in urinary tract infections Wu Bing, Chen Cui-hong, Tong Hua-cheng (1.Department of pharmacy, 2.Department of Laboratroy, Nanjing Tongren Hospital Affliated to Medical College of Southeast University，Nanjing 211102，China) 【Abstract】 Objective To investigate the distribution and drug resistance of pathogens in the patients who suffered from urinary tract infections(UTI), then help to improve the clinic using antibiotic agents rationally. Methods A total of 139 patients with UTI and positive results of urine culture were admitted into hospital from March 2012 to September 2013, their medical records were retrospectively investigated, drug-resistance of pathogens and empirical antibiotic treatments were evaluated. Results 142 strains were isolated from the 139 patients. The isolates included Gram-negative bacteria were 68.4%, Gram-positive bacteria were 24.6% and fungi were 7.0%. Escherichia coli(44.6%) and enterococcus( 14.8%) were the main pathogens.The rates of Gram-negative bacilli resistant to imipenem, amikacin, cefoperazone/sulbactam and piperacillin/tazobactam were 0～19.2%. No isolate of Gram-positive cocci was found resistant to vancomycin, linezolid and teicoplanin , the susceptible rate was 100%. The rate of Candida bacteria resistant to fluconazole was 20%. 113(81.3%) patients received empirical anti-infective therapy before the drug susceptibility tests, only 46.9% were correspond with the final outcome. Quinolone was the most frequently used for empirical treatment, with a usage rate 62.8%. Conclusions Empirical drug treatments meet drug susceptibility testing results with a lower rate. The characteristics of the distribution and drug resistance of pathogens