局部晚期鼻咽癌放射治疗的研究进展徐瑾.pdfVIP

·156 · , 　 〖 ·〗 徐瑾, 　郝俊芳 山东省肿瘤医院放疗科, 山东 济南250117 Progress in the treatment of local advanced nasopharyngeal carcinoma X U J in, H A O J un -f ang D ep ar tmen t of R ad ia tion Onco logy , S hand ong Cancer H osp ita l, J inan 250117, P .R .Ch ina 【】　:分析局部晚期鼻咽癌治 [ABSTRACT] 　OBJECTIVE:T o summarized the recent pro ress in 疗的国内外研究现状和进展, 为临床治 the treatment of local advanced nasopharyn eal carcinoma.MET ODS: 疗提 依据。 :应用 PubMed 和 The PubMed system and CNKI databases w ere searched usin the key - CNKI 等数据检索系统及数据库, 以“鼻 words nasopharyn eal carcinoma and therapy, published from Jan. 咽肿瘤和放 射治疗”等为关键词检索 2000 to Jun.20 10.Criteria of paper adoption:1)Clinical study of na- 2000-0 1-2010-06 的相关文献, 纳入标 sopharyn eal carcinoma includin the methods, result, and pro res- 准:1)鼻咽癌治疗的临床试验, 包括方 ses;2)Analy sis the efficacy, side effects of radiotherapy, chemother- 法、结果和进展;2)鼻咽癌放疗、化疗及 apy and other therapies.Accordin to the above criteria, 27 papers 其他治疗的疗效及不良反应。根据纳入 were finally selected for analyzed and reviewed.RESULTS:All of 标准符合分析的文献 27 篇。:各种 these different therapies make some improvement.And most of resear- 治疗方法的临床研究均取得了一定的进 ches focus on the intensity modulated radiation therapy (IMRT), IM- 展, 其中调强放疗的应用使局部晚期鼻咽 RT brin s local control rates up to more than 90%and obviously de- 癌的局部控制率90%, 且使得放疗的急 creases the side effects compared with the conventional radiotherapy 慢性不良反应较常规放疗明显减轻,但同 with better sparin of the surrounded normal tissue, w hile IM RT need 时也对靶区的确定和勾画提出了更为严 more strictly request for the tar et coutoured.Combine chemotherapy 格的要求。联合化疗在提高总生存率及 with radiotherapy can reduce the metastasis