薑黃素的生物效應.pdfVIP

元 培 學 報 Journal of Yuanpei University 第十 五期民國 97 年12月 No. 15, December 2008 1 ～ 10頁 P. 1 ～ P. 10 薑黃素的生物效應 The Biological Effects of Curcumin 謝明祥 Ming-Xiang Xie 黃文濤 Wen-Tao Huang ∗ 林玴竹 Yi-Zhu Lin 施科念 Ko-Nian Shih 元培科技大學放射技術系 Department of Radiological Technology, Yuanpei University (Received, November 18, 2008; Revised, December 6, 2008; Accepted, December 30, 2008) 摘 要：薑黃素(Curcumin) ，是屬於薑科植物的一種，通常被使用在黃色染料和食品香料上。 最近在許多文獻研究已證實薑黃素有許多的醫學特性，分別在動物實驗和分子生物研究皆能 顯示出有抑制環氧化酶(cyclo-oxygenase-2 ；COX-2)和細胞激素(cytokines)達到抗發炎的作 用，有能力抑制基質金屬蛋白酶 (matrix metalprotease)的活性，減少對細胞外基質降解，避 免腫瘤細胞侵襲到鄰近組織，並能調節Bcl-2 和caspase 的活化進而誘導癌細胞株凋亡，有抑 制核因子κB(nuclear factor kappa B ；NF-κB)和activating protein-1(AP-1)等轉錄因子的活化， 減少發炎反應與腫瘤增生等生物效應。這篇文獻回顧主要描述薑黃素在動物實驗與分子生物 研究上的化學預防效應與生物機轉。 關鍵詞：薑黃素、抗發炎、抗腫瘤和核因子κB Abstract: Curcumin is one kind of Zingiber plant, usually used on yellow dyestuffs and food spices. It has already verified by many studies the curcumin has a lot of medical characteristics, and can be demonstrated in animals experiment and molecular biological studies. Curcumin has the ability of anti-inflammation through suppressing cyclo-oxygenase-2 (COX-2) and cytokines, prevent tumor metastasis from blocking matrix metalproteases (MMP2 and MMP9), and can ∗ Corresponding author 1 regulate the activation of Bcl-2 and caspases then induce cancer cells to apoptotic program. On the other hand, it can inhibit the transcriptional activation of nuclear factor kappa B (NF- kB) and activating protein-1