大型海藻多糖_琼脂糖的改性及作为皮肤敷料的研究_琼脂糖接枝透明质酸海绵再生皮肤试.pdfVIP

28 1 Vol.28 No. 1 2011 2 Journal of Biomedical Engineering February 2011 ( ) * 1, 2 1 1 1 1 黄建艳 张灵敏 储 彬 陈 鹏 汤顺清 1 ( 暨南大学 生物医学工程研究所, 广州510632) 2 ( 广东冠昊生物科技股份有限公司, 广州510670) : ( A ggH A ) , , A ggH A , bFG F , , , H E , , : ; ; R3 18. 0 8; T B39 A 100 15515( 2011) Modification of Seaweed olysaccharideagarose and Its Application as Skin Dressing ( ) Skin Regeneration with Agarose Grafting Hyluronic Acid Sponge 1, 2 1 1 1 1 Huang Jianyan Zhang Lingmin Chu Bin Chen eng Tang Shunqing 1 ( Bi omed i cal Eng inee ri ng I nsti tu te , J inan Unive rs i ty , Guang z ho u 5 10632, Chi na) 2 ( Guang dong G rand hop e B iote chnolog y Coop er ati on, Guang z ho u 5 10670, Chi na) Abstract: In th s paper, a k nd of sk n dr ess ng , agar oseg r aft ng hyalur on c ac d ( A ggH A) spong e w as appl ed to test the mod f ed agar ose based scaffo ld fo r sk n regenerat on . T he bFGF load ng agar osegr aft ng hyalur onan scaf fold had ho mog enou s poro s t es, and the loaded bFG F w as b oact v e n 2 w eeks . T he AggHA sponge w as appl ed nto sk n of m ce, and t w as fo und that t he dr ess ng pro moted sk n r egenerat o n and no nf ect o n and leakage n les on s te to ok place. H E sta n ng r esults sho w ed that the r epa red sk n w as s m lar to aut olo go us sk n . T hese demo n strate that A ggH A sponge has a prom se n sk n reg ener at o n. Key words: A gar osegr aft nghy aluro n c ac d ( AggHA ) ; Sk n r