513例ADR报告的Pareto最优分析.pdfVIP

中国药物应用与监测 2014 年6 月第11卷第3 期 Chinese Journal of Drug Application and Monitoring, Vol.11, No.3, June 2014 513 例ADR 报告的Pareto 最优分析 1 2 1 2 （1.象山县食品药品监督管理局，浙江 宁波 315700 ；2. 宁波市鄞州区第二医院，浙江 宁波 谢灵璞 ，徐锦龙 ，莫燕红 ，陈　武 315100 ） [摘要]　目的：探讨2012 年象山县不良反应发生的规律和特点，为临床合理用药提供参考。方法：采用Pareto 最优分析，对 2012 年填写上报的513 例ADR 报告进行整理，从患者年龄、给药途径、抗菌药物品种、严重和新的ADR 及相关临床表现等 方面进行分析和归纳。结果：513 例ADR 报告中，男性203 例（39.6% ），女性310 例（60.4% ），发生ADR 患者主要年龄段在30 岁以上，尤其是60 岁以上的老年人是高发群体；主要给药途径为静脉滴注；涉及药物种类主要为抗菌药物；发生严重的和新 的ADR 共271 例（52.8% ）。结论：应加强对患者的用药监护，做到个体化给药，以减少ADR 的发生，确保临床用药安全、有 效。 [关键词]　Pareto 最优；药品不良反应；分析 [ 中图分类号]　R969.3　　 [ 文献标识码]　A　 [ 文章编号]　1672 – 8157(2014)03 – 0177 – 03 Pareto optimal analysis of 513 cases of ADR reports 1 2 1 2 XIE Ling-pu , XU Jin-long , MO Yan-hong , CHEN Wu (1. Xiangshan Food and Drug Administration, Ningbo 315700, China; 2. Ningbo Yinzhou NO.2 Hospital, Ningbo 315100, China) [ABSTRACT]　Objective: To investigate the characteristics of adverse drug reaction of Xiangshan country in 2012 for providing references about rational drug use. Methods: The Pareto optimal analysis was adopted to analyze the ADRs in respect of the patients age, route of administration, antimicrobial varieties, the severe and new ADRs as well as drug-related clinical manifestations. Results: Among the 513 ADR cases, 203 cases (39.6%) were male and 310 cases (60.4%) were female. Most cases were more than 30 years old. The patients over 60 years old were at high risk of ADRs. The main route of administration was intravenous drip. Antibacterials were mostly involved in 513 ADR reports. A total of 271 cases (52.8%) were severe and new ADRs. Conclusion: Pharmaceutical care and individual regime should be strengthened to improve rational drug use and reduce the occurrence of ADRs. [KEY WORDS]　Pareto optimal; Adverse drug reaction; Analysis “Pareto 最优”也称为80/20 法则，以意大利经济