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l e t t e r s Common variants at 19p13 are associated with susceptibility to ovarian cancer Epithelial ovarian cancer (EOC) is the leading cause of death Associations between SNP genotypes and survival were evaluated from gynecological malignancy in the developed world, using a 1 degree-of-freedom trend test based on the Cox model  accounting for 4% of the deaths from cancer in women . (Online Methods). The 4,649 SNPs showing the strongest evidence for We performed a three-phase genome-wide association study association with EOC survival were selected for genotyping in phase . of EOC survival in 8,95 individuals with EOC (cases) with 2 together with 22,790 SNPs selected for the susceptibility study and d e available survival time data and a parallel association analysis 800 SNPs that are highly informative on ancestry. Phase 2 comprised v r of EOC susceptibility. Two SNPs at 9p3., rs870 and 4,238 cases and 4,810 controls from ten different studies across the e s rs2363956, showed evidence of association with survival United States, Europe and Australia, and SNPs were genotyped in e r s (overall P = 5 × 0–4 and P = 6 × 0–4, respectively), phase 2 using a custom Illumina iSelect array. The majority of cases t h but they did not replicate in phase 3. However, the same (80%) had survival time data available through a variety of sources, g i r two SNPs demonstrated genome-wide significance for risk including death certificate fla