中西医结合治疗对重症急性胰腺炎患者血清抵抗素的影响：随机对照临床试验.pdfVIP

中西医结合学报 2009年 12月第 7卷第 12期 JournalofChineseIntegrativeMedicine，December2009，Vo1．7，No．12 ·1135 · resistinJevelsjnSAPpatjents． Design，setting，participantsand interventions：Twenty—eightSAP patientsmeeting inclusion criteria from DepartmenioflntegratedTraditionalChineseandWesternMedicine。WesiChinaHospital。SichuanUniversity wereincluded。and thepatientswererandomlydividedintotreatmentgroupandplacebogroup．Therewere 13patientsinthetreatmentgroupand15patientsintheplacebogroup．Patientsinthetreatmentgroupwere aiven{radIlionaIChineseherbalmedicine inaddiiionto ihe conveniionaltreatment．Patientsin ihe Placebo grouPwereaiyenplacebo inadditionto theconventionaftreatment． Mainoutcomem easures：Theserum resistinleveIsonadmIssion，anddaysl，3，5，and7afterlheadmIssion weredetected Results：Theserum resistinleveIsonadmission inallthe patientswere higherthannormaIlevel，and there wasnosignificantdifferencebetweentheiwogroups (P O．05)．0ndays1，3，5，and7afteradmission， theresistinlevelsinthetreatmentgroupwere(3．294-1．66)fig／L，(3．714-1．05)fig／L，(3．08±1．47)fig／L and(3．62±1．67)fig／L，andinthecontrolgroup (5．16±1．93)fig／L，(5．07± 1．53)fig／L，(4．88± 1．47)fig／Land(5．12±1．48)fig／L，respectively．Theresistinlevelswerelowerinthetreatmentgroupthan jnthecontroJaroup (尸dO．05)， Conclusion：Serum resistin IeveIinSAPpalientscanbedecreasedby integrated traditiona1Chinesemedicine andWesternmedicinetherapy． 、 Keywords：severeacutepancreatitis；resistin；integratedtraditionalChineseandWesternmedicine；placebo； prospectivestudies；randomizedcontrolledtrial 急性胰腺炎 (acutepancreatitis，AP)是临床常 9．2 g／L时，胰腺坏死 的阳性预测值为91．9 。AP 见的急腹症之一 ，近年来发病率呈上升趋势 ，其 中 患者中抵抗素升高者病情重 ，预后差 ，抵抗素有望成 20 左右属重症[1。重症急性胰腺炎 (severeacute 为评价 AP严重程度的一种新的标记物 。 pancreatitis，SAP)病情发展迅猛 ，早期即可发生全 中西医结合治疗 SAP充分体现 了中医的整体 身炎 症反 应综 合征 (systemicinflammatoryre— 观，即对病变在局部而反应在全身的SAP进行分期 sponsesyndrome，SIRS)，从而导致多器官功能障 分型和辨证论治 ，运用通里攻下和活血化瘀法等 ，使