激酶复合物Cdc2%2fcyclin+B1对中心体蛋白Bacp%2fNlp调控机制研究.pdf

洲Y㈣2洲3删4舢0川6 ¨¨¨¨●I ㈣2 本论文的研究工作是在国家重点基础研究发展规划项 在此表示诚挚的谢意! Thethesiswas theChina11na aetsupportedroppbyUSyeKRey onBasic 31 Program Research(No．2002CB5101)．We are forthe gratefullyappreciatedsupport． 一一 一 一 目 录 目录一一一一一一一一一一一一一一一一一一一一一一一一～一一一一一一一一一一一一一一一一一一一一一3 缩略语表一一一一一一一一一～一一一一一一一一一一一一一一一一一一一一一一一一一一一～一一一一5 中文摘要一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一9 英文摘要一一一一一一一一一一一一一一一～一一一一一一一一一一一一一一一一一一一一一一一一一一11 前言一一一一一一一一一一一一一一一一一一一一一一一一～一一一一一一一一一一一一一一一一一一一一1日U舌一一一一一一一一一一一一一一一一一一一一一一一一～一一一一一一一一一一一一一一一一一一一一13 材料与方法一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一～一一一23 实验材料一一一一一一一一一～一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一23 研究方法一一一一一一一一一～一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一31 结果一一一一一一一～一一一一一一一一一一～一一一一一一一一一一一一一一一一一一一一一～一一一47 讨{仑一一一一一一一一一一一一一一一一一一一一一一一一～一一一一一一一一一一一一一一一一～一一一73 ／J、结一一一一一一一一一一一一一一一一一一一一一一一一～一一一一一一一一一一一一一一一一一一一一81 参考文献一一一一一一一一一～一一一一一一一一一一一一一一一一一一一一一一一一一一一～一一一83 文南Ii综述一一一一一一一一一～一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一95 附录一一一一一一一一一一一一一一一一一一一一一一一一～一一一一一一一一一一一一一一一一一一一115 致谢一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一一117 声明一一一一一一一一一一一一一一一一一一一一一一一一～一一一一一一一一一一一一一一一一一一一119 4 缩略语表 缩写词 英文 中文 AA Aminoacid 氨基酸 APC Anaphasepromotingcomplex 后期促进复合物 APC2 Anaphasepromotingsubunit2 后期促进复合物亚单位2 complex APS 过硫酸铵 Aminopropyltriethoxysilane Abnormal 异常纺锤体蛋白 Asp spindleprotein BRCA1 associatedcentrosomal BRCA Bacp