松弛素在心血管疾病中的研究进展.pdfVIP

第22卷 第8期 生命科学 Vol. 22, No. 8 2010年8月 Chinese Bulletin of Life Sciences Aug., 2010 文章编号 ：1004-0374(2010)08-0772-06 松弛素在心血管疾病中的研究进展 1 2* 高　照 ，李法琦 (1海南省人民医院康复医疗中心，海口 570311；2 重庆医科大学附属第一医院老年病科，重庆 400016) 摘　要：松弛素是一类新近发现可作用于心血管的肽类激素，参与心血管系统的生理和病理过程。大 量实验研究显示松弛素有扩血管、改善心血管重塑及调节炎症反应的心血管保护作用，也有利于改善高 凝状态和胰岛素抵抗。松弛素作用广泛，可与松弛素受体或糖皮质激素受体结合，但其受体后的确切 机制以及不同生理和病理状态对松弛素的调控还需进一步基础研究阐明。在从实验室到临床应用转化的 初期临床试验中可观察到，人重组松弛素治疗急慢性心力衰竭安全性好，可改善症状、血流动力学指 标及近期预后，为Ⅲ期临床试验奠定了基础，其临床应用前景令人期待。 关键词：松弛素；心血管系统；临床试验 中图分类号：Q516; R54 文献标识码：A Research advances of relaxin and its role in cardiovascular diseases    1 2 GAO Zhao , LI Fa-qi * (Medical Rehabilitation Center, Hainan Provincial People’s Hospital, Haikou 570311, China; 2 Department of Gerontology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China) Abstract: It is recently found that relaxin (RLX), a peptide hormone, has an action on heart and vessels, involved in the physiologic and pathological processes of cardiovascular system. Accumulating studies have docu- mented that RLX has cardiovascular protective effects on systematic vasodilation, cardiovascular remodeling and inflammatory reaction, and improves hypercoagulative state and insulin resistance as well. RLX exerts multiple effects, where the exact mechanisms behind the receptor-binding and modulation of RLX under differ- ent physiologic or pathologic conditions still need further elucidation. In translation of experimental findings to clinic therapy, the clinical trials on compensatory and acute heart f