复方浙贝颗辅助化疗对RAL患者KPS评分与症状影响的临床观察.docVIP

 n 复方浙贝颗辅助化疗对 RAL 患者 KPS 评分 与症状影响的临床观察 王珺1，陈信义2** 5 10 15 20 25 30 35 （1. 北京中医大学东直门医院,北京市 100700； 2. 北京中医药大学东直门医院，北京市 100700） 摘要：急性白血病（AL）是造血干细胞的恶性克隆性疾病，发病时骨髓中异常的原始细胞 及幼稚细胞（白血病细胞）大量增殖并广泛浸润肝、脾、淋巴结等各种脏器，抑制正常造血。 近 20 年来，随着科技的发展，化疗手段的日趋进步，急性白血病（AL）近、远期疗效均比 以往有显著提高，无论是完全缓解率（CR）期还是无病生存率（DFS）。但是仍有 10%-20% 的 AL 经经典的化疗方案不能达到 CR，变为难治。这部份病例称之为难治性急性白血病 （Refractory acute leukemia，RAL）。RAL 主要特点为对化学治疗反应差，诱导缓解率低， 生存期短，因而是白血病治疗中的难题。所以，目前有学者已从针对难治性急性白血病临床 缓解率的研究，转向对难治性急性白血病患者生活质量影响的研究。本课题则以“复方浙贝 颗粒”辅助化疗对难治性急性白血病患者 KPS 评分与症状影响的临床观察为主要目的。 关键词： 复方浙贝颗粒；KPS 评分；临床症状；难治性急性白血病 中图分类号：R273 中医肿瘤科 Observe and research the influence on symptoms and KPS scores after using Fritillary Thunbergii Bulb Complex Granules (FTBCG) WANG Jun, CHEN Xinyi (Dongzhimen hospital affiliated to Beijing university of Chinese medicine) Abstract: Acute leukemia (AL) is a malignant clonal disease of hematopoietic stem cells. The liver, spleen, lymph nodes and other organs are extensively infiltrated by the abnormally proliferated progenitor cells and immature cells (leukemia cells) of the marrow which inhibit normal hematopoiesis. In the past 20 years, with the development of science and technology and the increasing means of chemotherapy, the long-term efficacy of treatment for acute leukemia (AL) has been significantly improved than the past, either in complete remission (CR) or disease free survival. But 10%-20% of the AL after chemotherapy still can not reach the classic CR, which becomes intractable. This part of the case is called refractory acute leukemia (Refractory acute leukemia, RAL). RAL is characterized by a poor response to chemotherapy, induction of remission rate, and short survival; therefore, it is the major challenge in the treatment of leukemia. Above all, the change from the clinical remission rate of acute leukemia to the treatment of refractory acute leukemia patients’ quality of life research. In this study, Fritillary Thunbergii Bulb Complex Granules (FTBCG) combined with chemotherapy w