Pimasertib-hydrochloride-AS703026-hydrochloride-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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Pimasertibhydrochloride

Cat.No.:HY-12042A

CASNo.:1236361-78-6

Synonyms:AS703026hydrochloride;MSC1936369Bhydrochloride

分⼦式:C₁₅H₁₆ClFIN₃O₃

分⼦量:467.66

作⽤靶点:MEK

作⽤通路:MAPK/ERKPathway

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Pimasertibhydrochloride是⼀种⾼效，具有选择性，⼝服活性的、ATP⾮竞争性的MEK1/2别构抑制剂，主

要⽤于癌症研究。

客户使⽤本产品发表的科研⽂献

•Cell.2023Jun22;186(13):2929-2949.e20.

•SciTranslMed.2018Jul18;10(450).pii:eaaq1093.

•SciAdv.2023Mar22;9(12):eadd5028.

•SciData.2024Sep19.

•Oncogenesis.2019Nov4;8(11):65.

Seemorecustomervalidationsonwww.MedChemE

REFERENCES

[1].KimK,etal.BlockadeoftheMEK/ERKsignallingcascadebyAS703026,anovelselectiveMEK1/2inhibitor,inducespleiotropicanti-

myelomaactivityinvitroandinvivo.BrJHaematol,2010,149(4),537-549.

[2].YoonJ,etal.MEK1/2inhibitorsAS703026andAZD6244maybepotentialtherapiesforKRASmutatedcolorectalcancerthatis

resistanttoEGFRmonoclonalantibodytherapy.CancerRes,2011,71(2),445-453.

[3].ParkSJ,etal.TheMEK1/2inhibitorAS703026circumventsresistancetotheBRAFinhibitorPLX4032inhumanmalignantmelanoma

cells.AmJMedSci.2013Dec;346(6):494-8.

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