PPTN-mesylate-生命科学试剂-MCE.pdf

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PPTNmesylate

Cat.No.:HY-103055

CASNo.:1160271-31-7

分⼦式:C₃₀H₂₈F₃NO₅S

分⼦量:571.61

作⽤靶点:P2YReceptor

作⽤通路:GPCR/GProtein

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性PPTNmesylate是⼀种有效，⾼亲和⼒，竞争性和⾼选择性的P2Y14受体拮抗剂，KB为434pM。PPTN

mesylate对P2Y1，P2Y2，P2Y4，P2Y6，P2Y11，P2Y12或P2Y13受体⽆激动剂或拮抗剂作⽤。具有抗炎和

免疫活性[1]。

REFERENCES

[1].BarrettMO,etal.Aselectivehigh-affinityantagonistoftheP2Y14receptorinhibitsUDP-glucose-stimulatedchemotaxisofhuman

neutrophils.MolPharmacol.2013Jul;84(1):41-9.

[2].LinJ,etal.TheP2Y14receptorinthetrigeminalganglioncontributestothemaintenanceofinflammatorypain.NeurochemInt.2019

Dec;131:104567.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

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