Nanatinostat-TFA-CHR-3996-TFA-生命科学试剂-MCE.pdf

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NanatinostatTFA

Cat.No.:HY-13432A

CASNo.:1256448-48-2

Synonyms:CHR-3996TFA

分⼦式:C₂₂H₂₀F₄N₆O₄

分⼦量:508.43

作⽤靶点:HDAC

作⽤通路:CellCycle/DNADamage;Epigenetics

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性NanatinostatTFA是⼀种有效的，有⼝服活性、I类选择性的组蛋⽩去⼄酰化酶(HDAC)抑制剂，IC50值为8

nM[1]。

客户使⽤本产品发表的科研⽂献

•CancerRes.2022Dec16;82(24):4542-4554.

Seemorecustomervalidationsonwww.MedChemE

REFERENCES

[1].MoffatD,etal.Discoveryof2-(6-{[(6-fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide(CHR-

3996),aclassIselectiveorallyactivehistonedeacetylaseinhibitor.JMedChem.2010Dec23;53(24):8663-78.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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