NF-56-EJ40-hydrochloride-生命科学试剂-MCE.pdf

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NF-56-EJ40hydrochloride

Cat.No.:HY-130246A

CASNo.:2728500-80-7

分⼦式:C₂₇H₃₁Cl₂N₃O₃

分⼦量:516.46

作⽤靶点:SuccinateReceptor1

作⽤通路:GPCR/GProtein

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性NF-56-EJ40hydrochloride是⼀种有效，⾼亲和⼒和⾼度选择性的⼈SUCNR1(GPR91)拮抗剂，IC50为25

nM，Ki为33.5nM，对⼤⿏SUCNR1⼏乎没有活性。NF-56-EJ40hydrochloride对⼈源化⼤⿏SUCNR1具有

⾼亲和⼒，Ki值为17.4nM。

客户使⽤本产品发表的科研⽂献

•JClinInvest.2024May7:e173214.

•DevCell.2022Sep8;S1534-5807(22)00596-2.

•CardiovascRes.2024May4:cvae102.

•Metabolism.2023Jun12;155630.

•CancerLett.2021Nov20;S0304-3835(21)00591-7.

Seemorecustomervalidationsonwww.MedChemE

REFERENCES

[1].HaffkeM,etal.Structuralbasisofspecies-selectiveantagonistbindingtothesuccinatereceptor.Nature.2019Oct;574(7779):581-585.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.