Mepazine-acetate-Pecazine-acetate-生命科学试剂-MCE.pdf

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Mepazineacetate

Cat.No.:HY-121282B

CASNo.:24360-97-2

Synonyms:Pecazineacetate

分⼦式:C₂₁H₂₆N₂O₂S

分⼦量:370.51

作⽤靶点:Apoptosis;MALT1

作⽤通路:Apoptosis;MetabolicEnzyme/Protease;NF-κB

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Mepazineacetate(Pecazineacetate)是⼀种药物，具有抑制MALT1蛋⽩酶活性的活性。Mepazineacetate常

被⽤于研究MALT1在⽣物学中的作⽤。Mepazineacetate对⼩⿏⾻髓前体细胞的处理强烈抑制了RANK配体（

RANKL）诱导的破⾻细胞形成。Mepazineacetate还抑制了多种破⾻细胞标志物的表达，如TRAP、猫hepsin

K和降钙素。Mepazineacetate的保护作⽤不受MALT1缺乏的影响。Mepazineacetate的作⽤机制可能涉及

MALT1独⽴的机制，这⼀⽅⾯在未来的研究中需要加以考虑。

客户使⽤本产品发表的科研⽂献

•Blood.2022Jul27;blood.2022016424.

•IntJMolSci.2023Apr17;24(8):7402.

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REFERENCES

[1].NagelD,etal.PharmacologicinhibitionofMALT1proteasebyphenothiazinesasatherapeuticapproachforthetreatmentofaggressive

ABC-DLBCL.CancerCell.2012Dec11;22(6):825-37.

[2].MepazineInhibitsRANK-InducedOsteoclastogenesi