Mitapivat-hemisulfate-AG-348-hemisulfate-生命科学试剂-MCE.pdf

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Mitapivathemisulfate

Cat.No.:HY-12689B

CASNo.:2329710-91-8

Synonyms:AG-348hemisulfate

分⼦式:C₂₄H₂₆N₄O₃S.₁/₂H₂SO₄

分⼦量:499.6

作⽤靶点:PyruvateKinase

作⽤通路:MetabolicEnzyme/Protease

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Mitapivathemisulfate是⼀种⼝服有效的丙酮酸激酶(pyruvatekinase)变构激活剂。Mitapivathemisulfate

在⼴泛的PKLR基因型中增加酶活性、蛋⽩质稳定性和ATP⽔平，具有恢复丙酮酸激酶缺乏的糖酵解途径活性

的潜⼒。Mitapivathemisulfate可⽤于丙酮酸激酶缺乏症的研究。

客户使⽤本产品发表的科研⽂献

•JSepSci.2024Jul;47(14):e2400173.

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REFERENCES

[1].KungC,etal.AG-348enhancespyruvatekinaseactivityinredbloodcellsfrompatientswithpyruvatekinasedeficiency.Blood.2017

Sep14;130(11):1347-1356.

[2].MatteA,etal.Thepyruvatekinaseactivatormitapivatreduceshemolysisandimprovesanemiainaβ-thalassemiamousemodel.JClin

Invest.2021May17;131(10):e144206.

[3].RabMAE,etal.AG-348(Mitapivat),anallostericactivatorofredbloodc