Sarizotan-hydrochloride-EMD-128130-hydrochloride-生命科学试剂-MCE.pdf

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Sarizotanhydrochloride

Cat.No.:HY-100820A

CASNo.:195068-07-6

Synonyms:EMD128130hydrochloride

分⼦式:C₂₂H₂₂ClFN₂O

分⼦量:384.87

作⽤靶点:5-HTReceptor;DopamineReceptor

作⽤通路:GPCR/GProtein;NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Sarizotanhydrochloride是具有⼝服活性的5-HT1A受体和多巴胺受体的激动剂，其IC50值分别为6.5nM

(rat5-HT1A)、0.1nM(human5-HT1A)、15.1nM(ratD2)、17nM(humanD2)、6.8nM(humanD3)和2.4

nM(humanD4.2)。

客户使⽤本产品发表的科研⽂献

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REFERENCES

[1].GDBartoszyk,etal.Sarizotan,aSerotonin5-HT1AReceptorAgonistandDopamineReceptorLigand.JNeuralTransm(Vienna).2004

Feb;111(2):113-26.

[2].CMarin,etal.LocalAdministrationofSarizotanIntotheSubthalamicNucleusAttenuatesLevodopa-InducedDyskinesiasin6-OHDA-

lesionedRats.Psychopharmacology(Berl).2009Jun;204(2):241-50.

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