MLN8054-sodium-生命科学试剂-MCE.pdf

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

MLN8054sodium

Cat.No.:HY-10180A

CASNo.:869366-15-4

分⼦式:C₂₅H₁₄ClF₂N₄NaO₂

分⼦量:498.84

作⽤靶点:AuroraKinase

作⽤通路:CellCycle/DNADamage;Epigenetics

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性MLN8054sodium是⼀种AuroraA抑制剂，具有增强放射敏感性的活性。MLN8054sodium在体外实验中能够

激活前列腺癌细胞的DNA双链断裂反应。MLN8054sodium的应⽤与细胞周期G2/M阶段的积累和多倍体形成

密切相关。MLN8054sodium在体内实验中显⽰出与放疗联合使⽤能显著延缓前列腺癌肿瘤的⽣长，并促使肿

瘤细胞凋亡。

客户使⽤本产品发表的科研⽂献

•SciTranslMed.2018Jul18;10(450).pii:eaaq1093.

•CancerRes.2017Sep15;77(18):4785-4796.

•PLoSBiol.2020Jun9;18(6):e3000288.

•EMBORep.(2021)e51847.

•ComputStructBiotechnolJ.2019Feb8;17:352-361.

Seemorecustomervalidationsonwww.MedChemE

REFERENCES

[1].ManfrediMG,etal.AntitumoractivityofMLN8054,anorallyactivesmall-moleculeinhibitorofAuroraAkinase.ProcNatlAcadSciUS

A.2007Mar6;104(10):4106-11.

[2].HuckJJ,etal.MLN8054,aninhibitorofAuroraAkinase,inducessenescenceinhumantumorcellsbothinvitroandinvivo.MolCancer

Res.2010Mar;8(3):373-84.

[3].MLN8054,asmallmoleculeinhibitorofaurorakinasea,sensitizesandrogen-resistantprostatecancertoradiation

1/2Mast