MK-0752-sodium-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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MK-0752sodium

Cat.No.:HY-10975

CASNo.:656810-87-6

分⼦式:C₂₁H₂₀ClF₂NaO₄S

分⼦量:464.89

作⽤靶点:γ-secretase

作⽤通路:NeuronalSignaling;StemCell/Wnt

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性MK-0752sodium是⼀种⾼效、⼝服活性的特异性γ-分泌酶(γ-secretase)抑制剂，对⼈SH-SY5Y细胞A

β40呈剂量依赖性降低，IC50为5nM。MK-0752sodium穿过⾎脑屏障。MK-0752sodium降低体内新⽣的

中枢神经系统Aβ。

客户使⽤本产品发表的科研⽂献

•EMBOMolMed.2017Jul;9(7):950-966.

•Biofactors.2024Jul12.

•IntJMolSci.2022,23(11),5980.

•JCellPhysiol.2021Feb;236(2):1237-1251.

•Cancers(Basel).2024Jun10;16(12):2184.

Seemorecustomervalidationsonwww.MedChemE

REFERENCES

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amyloid-betaproductiontoalternativeAPPfragmentswithoutamyloid-betarebound.JNeurosci.2010;30(19):6743-6750.

[2].KropI,etal.PhaseIpharmacologicandpharmacodynamicstudy