Edicotinib-hydrochloride-JNJ-40346527-hydrochloride-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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Edicotinibhydrochloride

Cat.No.:HY-109086A

CASNo.:1559069-92-9

Synonyms:JNJhydrochloride;JNJ-527hydrochloride

分⼦式:C₂₇H₃₆ClN₅O₂

分⼦量:498.06

作⽤靶点:c-Fms

作⽤通路:ProteinTyrosineKinase/RTK

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Edicotinibhydrochloride是⼀种有效的、选择性的、具有⾎脑通透性和⼝服活性CSF-1R抑制剂，IC50为3.2

nM。Edicotinibhydrochloride对KIT和FLT3的抑制作⽤较⼩，IC50值分别为20nM和190nM。Edicotinib

hydrochloride抑制⼩胶质细胞的扩张，减弱⼩胶质细胞的增殖和神经退⾏性变。Edicotinibhydrochloride可

以⽤于阿尔茨海默病和类风湿性关节炎的研究[1][2]。

客户使⽤本产品发表的科研⽂献

•JExpMed.2023Mar6;220(3):

•MolSystBiol.2023Dec18.

Seemorecustomervalidationsonwww.MedChemE

REFERENCES

[1].MancusoR,etal.CSF1RinhibitorJNJattenuatesmicroglialproliferationandneurodegenerationinP301Smice.Brain.2019

Oct1;142(10):3243-3264.

[2].GenoveseMC,etal.ResultsfromaPhaseIIAParallelGroupStudyofJNJanOralCSF-1RInhibitor,inPati