Doxazosin-hydrochloride-UK-33274-hydrochloride-生命科学试剂-MCE.pdf

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

Doxazosinhydrochloride

Cat.No.:HY-W753806

CASNo.:70918-01-3

Synonyms:UK33274hydrochloride

分⼦式:C₂₃H₂₆ClN₅O₅

分⼦量:487.94

作⽤靶点:Others

作⽤通路:Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Doxazosinhydrochloride(UK33274hydrochloride)是⼀种⽤于抑制⾼⾎压和前列腺增⽣的化合物，具有抑制

⾎管平滑肌上突触后α1-肾上腺素受体的活性。Doxazosinhydrochloride可以导致⾎管扩张，从⽽降低外周⾎

管阻⼒。Doxazosinhydrochloride在⼩⿏肝纤维化模型中被发现能够抑制肝星状细胞的增殖和迁移。

Doxazosinhydrochloride通过激活PI3K/Akt/mTOR信号通路来调节肝星状细胞的纤维化、⾃噬和凋亡。

Doxazosinhydrochloride还阻⽌⾃噬流并诱导肝星状细胞的凋亡。

客户使⽤本产品发表的科研⽂献

•PLoSNeglTropDis.2019Aug20;13(8):e0007681.

Seemorecustomervalidationsonwww.MedChemE

REFERENCES

[1].DoxazosinAttenuatesLiverFibrosisbyInhibitingAutophagyinHepaticStellateCellsviaActivationofthePI3K/Akt/mTORSignaling

Pathway

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.