Deucravacitinib-hydrochloride-BMS-986165-hydrochloride-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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Deucravacitinibhydrochloride

Cat.No.:HY-117287A

CASNo.:1609392-28-0

Synonyms:BMS-986165hydrochloride

分⼦式:C₂₀H₂₀D₃ClN₈O₃

分⼦量:461.92

作⽤靶点:InterleukinRelated;JAK;IFNAR

作⽤通路:Immunology/Inflammation;Epigenetics;JAK/STATSignaling;

ProteinTyrosineKinase/RTK;StemCell/Wnt

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Deucravacitinibhydrochloride(BMS-986165hydrochloride)是⼀种⾼度选择性的全位点抑制剂，具有对TYK2

的强效抑制活性。Deucravacitinibhydrochloride能够有效阻断IL-12、IL-23和Ⅰ型⼲扰素信号传导。

Deucravacitinibhydrochloride在炎症性肠病的前临床模型中展现出显著的疗效。Deucravacitinib

hydrochloride与安慰剂和apremilast相⽐，在中度⾄重度斑块型银屑病的多个疗效终点上表现出优势。

Deucravacitinibhydrochloride在抑制中被良好耐受。

客户使⽤本产品发表的科研⽂献

•NatChemBiol.2022Dec;18(12):1388-1398.

•CellDeathDiffer.2021Feb;28(2):748-763.

•MolSystBiol.2023Dec18.

•IntJMolSci.2023May25,24(11),9243.

•IntJMolSci.2022May1;23(9):5040.

Seemorecustomervalidationsonwww.MedChemE

REFERENCES

[1].WrobleskiST,etal.HighlySelectiveInhibitionofTyrosineKinase2(TYK2)fortheTreatmentofAutoimmuneDiseases:Discoveryofthe

AllostericInhibitorBMS-986165.JMedChem.2019Jul18.

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