OB-24-free-base-生命科学试剂-MCE.pdf

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OB-24freebase

Cat.No.:HY-118487A

CASNo.:940061-39-2

分⼦式:C₁₅H₁₇BrN₂O₂

分⼦量:337.21

作⽤靶点:Others

作⽤通路:Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性OB-24freebase是⼀种强效且选择性地抑制⾎红素加氧酶1(HO-1)的化合物，具有抑制晚期前列腺癌的潜⼒。

OB-24通过选择性抑制前列腺癌细胞中的HO-1活性，显著减少蛋⽩质羰基化和活性氧种的形成。OB-24在体外

显著抑制细胞增殖，并在体内抑制肿瘤⽣长及淋巴结和肺转移。OB-24与Taxol联合使⽤时表现出强⼤的协同作

⽤。

REFERENCES

[1].Alaoui-JamaliMA,etal.Anovelexperimentalhemeoxygenase-1-targetedtherapyforhormone-refractoryprostatecancer.CancerRes.

2009;69(20):8017-8024.

[2].Anovelexperimentalhemeoxygenase-1-targetedtherapyforhormone-refractoryprostatecancer

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

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