糖代谢与胶质瘤细胞恶性生物学行为的关系_奚卓.pdfVIP

解剖科学进展　Progress of Anatomical Sciences　2020 Mar, 26(2): 230~233 糖代谢与胶质瘤细胞恶性生物学行为的关系 * * 奚　卓，张　睿，张富荣 （中国医科大学附属盛京医院第一神经外科, 辽宁 沈阳 110004） 【摘要】　胶质瘤是人体最常见 的中枢神经系统恶性肿瘤 ，由于其具有快速增殖 、浸润性生长 、易于复发 等恶性 的生物学行为特点 ，导致胶质瘤预后差 、致死率高 。糖代谢包括氧化磷酸化和糖酵解 ，而胶质瘤细胞仅 依靠氧化磷酸化产能并不能满足肿瘤细胞快速生长 的需求 ，因而胶质瘤细胞 的能量来源高度依赖于有氧糖酵 解 。有氧糖酵解不仅参与了胶质瘤细胞 的增殖和凋亡 ，影响着胶质瘤细胞 的迁移侵袭 ，还对胶质瘤多药耐药有 一定 的影响。因此 ，讨论糖代谢与胶质瘤细胞恶性生物学行为关系对于寻求治疗胶质瘤更好 的方法有重要 的临 床意义。 【中图分类号】　R739.41　【文献标识码】　A　【DOI 】　10.16695/j.cnki.1006-2947.2020.02.028 The relationship between glucose metabolism and malignant biological behavior of glioma cells * XI Zhuo , ZHANG Rui, ZHANG Fu-rong （Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang 110004, China） 【Abstract】　Glioma is the most common malignant tumor of the central nervous system in the human body. Due to its malignant biological behaviors such as rapid proliferation, invasive growth and easy recurrence, glioma has poor prognosis and high mortality. Glucose metabolism includes oxidative phosphorylation and glycolysis, and glioma cells rely solely on oxidative phosphorylation capacity to meet the rapid growth of tumor cells, therefore energy source of glioma cells is highly dependent on aerobic glycolysis. The aerobic glycolysis not only participates in the proliferation and apoptosis of glioma cells, but also affects the migration and invasion of glioma cells, and also has a certain effect on multidrug resistance of glioma. Therefore, discussing the relationship between glucose metabolism and malignant biological behavior of gl