在体微透析观察大鼠急性一氧化碳中毒后纹状体多巴胺及其代谢产物（职称论文资料）.docVIP

在体微透析观察大鼠急性一氧化碳中毒后纹状体多巴胺及其代谢产物（职称论文资料） 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：在体微透析观察大鼠急性一氧化碳中毒后纹状体多巴胺及其代谢产物 1 1 材料与方法 3 2 实验结果 5 4 讨论 5 文2：雌激素在大鼠杏仁核与纹状体多巴胺代谢中作用 7 参考文摘引言： 9 原创性声明（模板） 10 文章致谢（模板） 11 正文 在体微透析观察大鼠急性一氧化碳中毒后纹状体多巴胺及其代谢产物（职称论文资料） 文1：在体微透析观察大鼠急性一氧化碳中毒后纹状体多巴胺及其代谢产物 Characterization of Dopamine and Its Metabolites in the Striatum of Rats Due to Carbon Monoxide Poisoning as Determined by in vivo MicrodialysisGUAN Li，ZHAO Jin-yuan*，WEN Tao，ZHANG Yan-lin（Research Center of Occupational Medicine，The Third Hospital of Peking Univeity，Beijing 100083，China） Abstract：［Objective］ To explore the effect of Carbon monoxide（CO）poisoning on the changes of dopamine（DA）and its metabolites dihydroxyphenylacetic acid（DOPAC）and homovanillic acid（HVA）in the striatum of free-moving rats. ［Method］ Rats were divided at random into two groups，control group and CO intoxicated group. CO was injected into rats of the intoxicated group intraperitoneally at a dosage of 120 ml/kg for the fit time，and then repeated injectio with CO（60 ml/kg）for 3 times at 4 h intervals was amount of air was injected into the control rats intraperitoneally at the same levels in the blood of rats was measured for 24 hou after the fit CO administration，and changes of DA and its metabolites levels in the striatum was observed for 11 hou and at the 10th day after the last CO administration，as determined by mea of brain microdialysis. ［Results］ Compared to control group，HbCO level increased much higher and reached the peak at 1 to 2 hou after the fit CO administration，and it could be kept above 55% for 15 h. CO poisoning significantly changed extracellular DA and its metabolites level in the striatum and after 4-6 hou gradually recovered again. At the 10th day，DA level was remarkably decreased again，its metabolites increased. ［Conclusion］ When HbCO level returned to the normal level after the last CO administration，there were significantly changes again of DA and its metabolites. It