不同剂量米非司酮用药方案在治疗妇科疾病患者的疗效分析以及药理作用.docVIP

不同剂量米非司酮用药方案在治疗妇科疾病患者的疗效分 析以及药理作用 【摘要】目的:分析不同剂量米非司酮用药方案在治疗妇科疾病患者的疗效，并对其药理作 用进行探讨。方法:选取2015年4月?2017年1月我院收治的子宫肌瘤患者116例，随机将 其划分为观察组与对照组，各58例。2组均给予抑那通治疗，在此基础上对照组使用25 mg/d 米非司酮治疗，观察组采用12.5mg/d米非司酮治疗。对比2组患者临床疗效、子宫体积及 子宫肌瘤体积变化情况、月经情况与不良反应发生情况。结果:观察组总有效率84.48%与对 照组的70.69%比较差异无统计学意义(P0.05)； 2组治疗后子宫体积及子宫肌瘤体积均明 显小于治疗前(P0.05),且观察组均较对照组小(P0.05)； 2组治疗后FSH、LH、E2及P 水平均明显低于治疗前，且观察组各性激索水平均较对照组低(PV0.05)； 2组治疗后月经周 期均长于治疗前，行经期短于治疗前，月经量少于治疗前，口观察组月经周期较对照组长， 行经期较对照组短，月经量较对照组少(PV0.05)；观察组不良反应发生率较对照组低(P 0.05)o结论:在子宫肌瘤治疗中应用小剂量米非司酮，临床疗效更加显著，能有效降低患者 血清性激素水平，且不良反应较少。 【关键词】米非司酮；妇科疾病；药理作用；性激索；不良反应 Analysis on Curative Effect of Different Doses of Mifepristone Regimen in Treatment ofPatients with Gynecological Diseases and Pharmacological Effect [Abstract] Objective: To analyze curative effect of different doses of mifepristone regimen in treatment of patients with gynecological diseases and explore pharmacological effect. Methods: 116 cases of patients with hysteromyoma treated in our hospital from April 2015 to January 2017 were selected, and were divided into observation group and control group randomly, 58 cases in each group. All the two groups were given enantone treatment, on the basis of that, the control group were given 25 mg/d mifepristone treatment, and the observation group were given 12.5mg/d mifepristone treatment. Clinical effect, uterus volume and hysteromyoma volume change, menstruation and adverse reactions were contrasted in the two groups? Results: Total effective rate of the observation group was 84.48%, there was no statistically significant difference when compared with 70.69% of the control group (P 0.05). After treatment, uterus volume and hysteromyoma volume were significantly smaller than those before treatment in the two groups (P 0.05), and those in the observation group were smaller than those in the control group (P 0.05). The average levels of FSH, LH, E2 and P were significantly lower than those before treatment in the two groups, and sex hormones levels in the