中国医科大学妇产科学英文课件 OVARIAN CANCER.pptVIP

OVARIAN CANCER INTRODUCTION * I.Histologic Classification i.coelomic epithelium originating tumor accounts for 50-70% of primal ovarian tumor , 85-90% of ovarian malignace.developed from germinal epithelium→ primal coelomic epithelium →various muller,s epithelium →tubal epithelium,cervical mucosa epithelium,endometrium the coelomic epithelial tumors include (i).serous tumor (ii).mucinous tumor (iii).endometrioid tumor (iv).clear cell tumor (v).Brenner tumor/transitional cell tumor (vi).mixed epithelial tumor (vii).undifferentiated carcinoma ii.germ cell tumor accounts for 20-40% of ovarian tumor.germ cells originate from endogerm tissues.in the course of its origination, transformation and development the cellular heterogeneity may occur and form various tumors germ cell tumors include (i).dysgerminoma (ii).endodermal sinus tumor (iii).embryonic carcinoma (iv).polyembryonic tumor (v).choriocarcinoma (vi).teratoma i).immature type ii).mature type (a).solid teratoma (b).cystic teratoma a).dermoid cyst b).malignant change of dermoid cyst (c).monodermal and highly specialized tumors a).struma ovarii b).carcinoid (vii).mixed type iii.ovarian gonadal sex cord stromal tumor accounts for 5% of ovarian tumor.sex cord stroma originates from mesenchymal tissues of primal coelom female and male differentiation →epithelium differentiation→granulosa, Sertolic cell tumor functional tumor stromal differentiation →theca cell, Leydig cell tumor sex cord stromal cells tumor includes (i).granulosa cell-stromal tumor i).granulosa cell tumor ii).theca cell tumor,fibroma (ii).Sertolic-Leydig cell tumor i).androblas