抗菌环肽的研究进展-ChinaXiv.PDFVIP

抗菌环肽的研究进展 1 1 2 1* 戈家傲 ，刘畅 ，龚建刚 ，刘艳琴 河北农业大学理工学院 河北农业大学食品科技学院 河北 沧州 061100 摘 要：鉴于禽类细菌性疾病对养禽业健康发展的不利影响，人们急需开发改善细 菌耐药性的新型敏感性抗菌药物，使其达到治疗细菌性疾病的目的。环肽较线性肽因具 有更多的生物活性和医药价值而成为抗菌药物的候选者。本文主要从天然抗菌环肽的发 现、抗菌环肽的合成、环肽类抗菌药物的应用现状三个方面进行综述，期望有利于读者 进一步了解抗菌环肽的研究概况，为开发新型抗菌环肽药物提供帮助。 关键词：环肽；抗菌活性；抗菌机理；细菌性疾病；细菌耐药性 1 v 5 1 1 ResearchProgressofAntibacterial Cyclopeptides 0 0 . 1 1 2 1* 8 Jia-aoGE ,ChangLIU ,Jian-gang GONG ,Yan-qin LIU 0 College of ScienceandEngineering,College ofFood Science andTechnology, 8 AgriculturalUniversity ofHebei,Cangzhou,Hebei,061100,China 1 0 2 1College of ScienceandEngineering,AgriculturalUniversity ofHebei,Cangzhou, : v Hebei,061100,China i X a 1College of ScienceandEngineering,AgriculturalUniversity ofHebei,Cangzhou, n i Hebei,061100,China h c 2 College ofFood ScienceandTechnology,AgriculturalUniversity ofHebei,Baoding, Hebei,071000,China 1*College of ScienceandEngineering,AgriculturalUniversity ofHebei,Cangzhou, Hebei,061100,China Abstract ：In view of the adverse effects of avian bacterial diseases on the healthy development of the poultry industry, there is an urgent need to develop new sensitive antimicrobial agents that improve bacterial resistance so as to achieve the purpose oftreating bacterial diseases. Cyclic peptides are candidates for antibacterials because they have more