脑梗死急性期患者血小板活化因子治疗前后的变化.docVIP

脑梗死急性期患者血小板活化因子治疗前后的变化 ［摘要］目的探讨脑梗死急性期患者血小板活化因子(PAF) 的变化及意义。方法 选择2014年5月?2015年5月在温州市 中西医结合医院就诊的脑梗死患者，且发病时间在6?24 h,选 取40例为观察组，另选健康者20例作为对照组，观察组治疗前 及治疗后第2、3、7、14天用酶联免疫吸附双抗夹心法试验测定 血小板活化因子(PAF)的浓度，20例健康者早晨空腹静脉血作 为正常对照组。采用NIHSS评分对所有观察组患者治疗前的神经 功能及治疗后的神经功能进行评分。结果 脑梗死患者治疗前 PAF 为(211. 31±11. 22)pg/mL 显著高于对照组的(155. 49±8. 7) pg/mL,差异有统计学意义(t二14.40, P0. 05), PAF在治疗后 第 3 天为(240.12 + 13. 78)pg/mL,达到高峰，7d 后为(215.33 ±16. 43) pg/mL,逐渐下降，14 d 后 PAF 水平(170. 27±11.40) pg/mL与治疗前的(211.31±11.22)pg/mL比较显著下降，差异 具有统计学意义(t二16.24, P0. 05)o脑梗死急性期患者NIHSS 与PAF浓度在治疗前和治疗后14 d呈正相关。结论 脑梗死急性 期血小板活化程度明显升高，经抗血小板治疗后明显下降，血小 板的行为改变是动脉粥样硬化性血栓性脑梗死形成的主要原因 之一。研究脑梗死急性期患者的血小板活化指标的变化规律，对 急性脑梗死诊断和治疗均有重要意义。动态检测有助于早期判断 病情的严重程度，并评估预后。 ［关键词］脑梗死；血小板活化因子(PAF)；血小板；神经 功能缺损评分；血小板活化 ［中图分类号］R743. 33 ［文献标识码］A ［文章编号］ 1673-9701 (2016) 24-0016-04 1.Department of Neurology , Wenzhou Hospital of Integrated Chinese and Western Medicine in Zhejiang Province , Wenzhou 325000 , China ； 2. Department of Neurology , the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China [Abstract] Objective To discuss the changes and significance of platelet activating factor (PAF) in patients with acute cerebral infarction. Methods A total of 40 patients with cerebral infarction within 6 to 24 h of onset treated in Wenzhou Hospital of Integrated Chinese and Western Medicine from May 2014 to May 2015 were selected as the observation group, and another 20 healthy volunteers were selected as the control group? The concentration of PAF in the observation group was detected before treatment and on day 2, 3, 7, and 14 days after treatment by ELISA double-antibody sandwich method? The fasting venous blood was detected in the control group? The neurological functions of patients were scored by NIHSS before treatment and after treatment. ResuIts The level of PAF in the observation group was (211. 31 +11. 22) pg/mL before treatment, which was significantly higher than that in the control group [ (155.49 + 8.7) pg/mL], (t二 14.40, P0. 0