蛋白质网络结构稳定性研究-计算机科学与技术专业论文.docxVIP

哈尔滨工业大学工学硕士学位论文 哈尔滨工业大学工学硕士学位论文 - - II - Abstract With the human genome projects progress, life science research has entered a post-genome era. In this era, the main fields of life science are functional genomics, structural genomics and proteomics research. Proteins have rules, such as post-translational modification, protein-protein interactions and protein conformation and other issues still depend on the study of proteins to solve. Although variability and diversity of protein led to it is far more complex than nucleic acid, it is these properties to participate in and influence the entire life process. Protein interaction study is an important aspect of proteomics. The phenomenon of life refers to many factors that will involve a number of proteins. The biological systems have relation with protein interaction, so the study protein complexes are important. Protein interaction studies can be broadly divided experimental method and calculation method. Calculation method is mainly based on the biological significance contained in the network of proteins, makes use of mathematical analysis method to draw conclusions. The paper introduces calculation method, specific complex stability assessment. First we introduced some current method of calculation study protein interactions, then a detailed analysis of the assessment of protein interaction IG2 stability of the method. This paper develops the assessment of protein interaction IG2 stability of the method, and develops three methods that evaluate protein complexes’ stability and analysis them in detail, The second mothed is developed based on the first method,the third method bases on the classify method. The system and result analysis are given. The purpose is to provide evaluation system which evaluates protein complexes’ stability for researchers who study protein complexes. Keywords protein-protein interaction, protein complexes, topological property,stability - - I - 目录 摘要 I HYPERLINK \l _bookmark0 Abstract