改性壳聚糖复合材料的制备与性能研究-化学专业论文.docxVIP

I I 摘 要 壳聚糖以其优良的生物学活性被广泛应用于制药和医用材料等医学领域。本文制 备了羧甲基化和异丁基化的壳聚糖，并将产物与 Ca2+反应，制备了含钙复合物和钙-异 丁基-壳聚糖复合物（新的化合物），采用红外光谱、紫外光谱、XRD 及 SEM 等分析 技术，对产物的结构进行测试，用自建体外促凝血和止血性能测试方法考察了所制备 样品的止血性能。结果表明，改性壳聚糖及其含钙复合物对小鼠尾部切断的外伤伤口 均有不同程度的止血作用，且含钙复合物的止血效果优于单纯改性的壳聚糖，其中钙- 异丁基-壳聚糖复合物的止血时间最短。本文所制得的新型 Ca2+-异丁基-壳聚糖不仅具 有异丁基-壳聚糖优异的生物相容性、无细胞毒性和可降解性，更有比异丁基壳聚糖更 好的溶解性和更快速的止血效果，可作为未来制备新型复合医用材料的优质原料。 关键词：壳聚糖系列复合物；Ca2+-异丁基-壳聚糖复合物；制备；表征；止血性能 II II ABSTRACT Chitosan has been widely used in medical fields such as pharmaceutical and medical materials with its excellent biological activities. In this paper, carboxyl-chitosan and isobutyl-chitosan were both prepared through reaction of chemical substitution, and the novel compounds, Ca2+-isobytul-chitosan, was obtained by reaction between chitosan and isobutyl-chitosan. Structure of products was tested by FT-IR, UV-vis, XRD and SEM, hemostatic properties of all products was examined through a self-builted testing method of clotting and hemostatic performance. The results showed that both the modificated chitosan and its calcium compounds have varying degress of hemostatic effect, on which the compounds was superior to the modificated chitosan only, and the shortest time of hemostatic was belonged to Ca2+-isobytul-chitosan compounds. The new type compounds that made in this perper, Ca2+-isobytul-chitosan, has many excellent properties such as biocompatibility, non poisonous to the cells and biodegradable, and the better solubility and more rapid effect on hemostatic than isobutyl-chitosan. Thus, this new type of compounds could be used as a quality raw materials of new medical materials in the future. Keywords: series compounds of chitosan; Ca2+-isobytul-chitosan; preparation; characterization; hemostatic effect PAGE PAGE IV 目 录 HYPERLINK \l _bookmark0 摘 要 I HYPERLINK \l _bookmark1 ABSTRACT II HYPERLINK \l _bookmark2 目 录 III HYPERLINK \l _bookmark3 第一章 绪论 1 HYPERLINK \l _bookmark4 1.1 引言 1 HYPERLINK \l _bookmark5 1.2 壳聚糖的简介 1 HYPERLINK \l _bookmark