人表皮干细胞的研究进展.docVIP

人表皮干细胞的研究进展 ?370?中国皮肤性病学杂志2007年6月第21卷第6期ChinJDermVenereol,June.2007,Vo1.21,No.6 RoleofeyotoxieTcelsinchonicalopecia areata[J].JInvestDermatol,2000,114 (1):112—116. [12]ZolerM,MeElweeKJ,EngelP,Hoffmann R.TransientCD44variantisoformexpression andreductioninCD4(+)/CD25(+)leg? ulatoryTcelsinC3H/HeJmicewithalope? eiaareata[J].JInvestDermatol,2002,I18 (6):983—992. [13]MeElweeKJ,Freysehmldt?PaulP,Hoffmann R,eto2.TransferofCD8(+)ceHsinduces localizodhaidosswhel~a8CIM(十)/CD25 (一)celspromotesystemicalopeeiaareata andCD4(+)/CD25(+)cellsblockade diseaseonsetintheC3H/HeJmousemodel [J].JInvestDermatol,2005,124(5):947 — 957. [14]TobinDJ,GardnerSH,LindseyNJ,eto2. Dipheneyproneimmunotherapyaltersanti— hairfollicleantibodystatusinpatientswitll alopeciaare~ta【J].EurJDermatol,2002,12 (4):327—334. [15]Freyschmidt—PaulP,HoannR,LevineE, SundbergJP,HappleR,MeElweeKJ.Cur- rentandpotentialagentsforthetreatmentof alopeciaa.re.ata[J].CurtPharmDes,2001,7 (3):213—230. [16]CotellessaC,PensK,CaraeeioloE,Morde? ntiC.ChimentiS.Theuseoftopicaldiphe? nyleyelopropenoneforthetreatmentofexten? sivealopeciaareata[J].JAmAcadDerma— tol,2001.44(I):73—76. [17]WisemanMC,ShapiroJ,MacDonaldN,Lui H.Predictivemodelforimmunotherapyof alopeciaareatawithdipheneyprone[J].Arch Dermatol.2001,137(8):1063—1068. [18]YamamotoS,JiangH,KatoR.Stimulation ofhairgrowthbytopicalappheationof FKS06,apotentimmunosuppressiveagent [J].JInvestDermatol,1994,102(2):160 — 164. [19]Freyschmidt—PaulP,ZieghrA,MeElwee KJ,eta1.Treatmentofalopeciaare~tain C3H/HeJmicewitllthetopicalimmunosup? pressantFKS06(Tacrolimus)[J].Europe? anJournalofDermatology,2001.II(5):405 — 409. [20]SkurkoviehB,SkurkoviehS.Anti—interfer- on?-gammaantibodiesinthetreatmentofau?- toimmunedisease[J].CurrOpinMdTher, 2003,5(1):52—57. [收稿日期】2006.11-09 [修回日期]2006.12.31 人表皮干细胞的研究进展 ProgressionOllResearchofHumanEpidermalStemCell 马慧群,冯捷,彭振辉 MAHui-qun,FENGJie,PENGZhen?hui [摘要]人类致命性的疾病多源自器官功能的丧失,而最理想的治疗手段莫过于由人体自身重新长出一个新的 组织或器官,对干细胞的探索使人们始终保持着这种重生的希望.皮肤作为人体组织的外在屏障,在抵御外环境物理 创伤中首当其冲