孟鲁司特钠辅助治疗成人支气管哮喘效果及对肺功能影响.docVIP

孟鲁司特钠辅助治疗成人支气管哮喘效果及对肺功能影响 　　[摘要] 目的 观察探讨使用孟鲁司特钠辅助治疗成人支气管哮喘时的治疗效果及其对患者肺功能的影响。 方法 将于2014年9月～2015年8月期间来我院就诊的400例成人支气管哮喘患者随机平均分为两组，分别为对照组和观察组，每组200例。对照组仅使用舒利迭进行治疗，观察组在对照组的基础上辅助使用孟鲁司特钠，两组均治疗15d，治疗前后记录比较患者的肺活量（FVC）、呼气峰值流速（PEV）、第一秒用力呼气容积（FEV1）、最大呼气流量占正常预计值的百分比（PEF%）等指标并比较治疗有效率。 结果 观察组患者治疗总有效率为92%，对照组治疗总有效率为75%，差异有统计学意义（P0.05），治疗后，两组患者情况都有明显改善，差异有统计学意义（P0.05），观察组较对照组而言差异更明显，差异有统计学意义（P0.05）。 结论 孟鲁司特钠辅助治疗成人支气管哮喘可以有效提高治疗有效率，改善患者肺功能，疗效明显，值得临床推广。 　　[关键词] 孟鲁司特钠；成人；支气管哮喘；舒利迭 　　[中图分类号] R562.25 [文献标识码] B [文章编号] 2095-0616（2016）09-84-03 　　[Abstract] Objective To study the treatment effect and investigate the therapeutic effect of Montelukast sodium auxiliary treatment on adult bronchial asthma and the influence on pulmonary function. Methods 400 adult patients with bronchial asthma in our hospital from September 2014 to August 2015were selected， and they were randomly divided into two groups，200 cases in each group.The patients in control group were treated by Seretide， patients in observation group were treated by Montelukast sodium on the basis of control group， all patients were treated for 15 days. The changes of forced vital capacity（FVC），peak expiratory velocity（PEV）， forced expiratory volume in one second（FEV1）， peak expiratory flow（PEF%） and other indicators in the two groups before and after treatment were recorded， and then the treatment efficiency of two groups were compared. Results The effective rate of observation group and the control group were 92% and 75%，the difference was statistically significant（P0.05），after treatment， the patients’ conditions have improved significantly in both groups（P0.05）， the differences of the observation group were more obviously than the control group， the differences were statistically significant（P0.05）. Conclusion Montelukast sodium auxiliary treatment of adult bronchial asthma can improve the therapeutically effective rate， improve patients pulmonary function， therapeutic effect is obvious， it is worth using widely. 　　[Key words]