MELD评分预测急性毒蕈中患者短期临床预后.docVIP

MELD评分预测急性毒蕈中毒患者短期临床预后 　　[摘要]目的 探讨终末期肝病模型（MELD）评分对预测急性毒蕈中毒所致肝功能损害患者短期预后的临床价值。方法 将我院感染消化科2014年7月～2017年9月收治的20例急性毒蕈中毒患者纳入研究，按照出院时生存与否分为生存组与死亡组，比较两组患者的相关观察指标。结果 12例生存，8例病情恶化死亡。两组的ALT、AST、TBil、Alb、SCr、WBC差异无统计学意义（P0.05），两组的MELD和凝血酶原活动度（PTA）差异有统计学意义（P=0.001，P=0.047）。以MELD绘制其判断患者短期预后的ROC曲线，曲线下面积为0.927。以MELD中国论文网 /6/viewhtm　　[关键词]急性毒蕈中毒；终末期肝病模型评分；预后 　　[中图分类号] R155.3 [文献标识码] A [文章编号] 1674-4721（2018）3（b）-0034-04 　　MELD score predicting short-term clinical prognosis in patients with acute mushroom poisoning 　　TIAN Xiao-li1 WU Song-lin2 WU Gang1 　　1.Department of Infection，Affiliated Hospital of Southwest Medical University，Sichuan Province，Luzhou 646000，China；2.Department of Critical Care Medicine，Affiliated Hospital of Southwest Medical University，Sichuan Province，Luzhou 646000，China 　　[Abstract]Objective To investigate the clinical value of model for end-stage liver disease （MELD） score predicting short-term prognosis in patients with acute mushroom poisoning which leads to liver function damage.Methods From July 2014 to September 2017，20 cases with acute mushroom poisoning admitted into infection and digestive department in our hospital were enrolled the study.According to whether there was survival or death at discharge，they were divided into the survival group and death group.The differences of clinical manifestation and experimental examinations were compared.Results There were 12 patients were survival and 8 patients dead due to deterioration of the condition.There was no great difference in alanine transaminase （ALT），aspartate aminotransferase （AST），total bilirubin （TBil），albumin （Alb），creatinine （SCr），and white blood cell （WBC）.MELD and prothrombin time activity （PTA） were displayed statistical differences （P=0.001，P=0.047）.The receiver operating characteristic （ROC） curve was drawn with MELD to determine the short-term prognosis，and the area under the curve was 0.927.MELD 　　1资料与方法 　　1.1一般资料 　　2014年7月～2017年9月，选取我院感染消化科收治的以肝功能损害为主要表现的毒蕈中毒患者20例，其中男14例，女6例；年