医药通心络保护内皮研究课件.pptVIP

THANK 保护内皮 一级预防 防治心脑血管病基础用药 * * Endothelial function predicts cardiovascular events: 5-year follow-up in angina patients The ability of endothelial function to predict long-term risk for cardiovascular events was studied in 73 patients with angina pectoris who were admitted to a hospital for coronary angiography to evaluate chest pain.3 Patients underwent brachial artery ultrasound to measure flow-mediated dilation (FMD) as an indicator of endothelial function at the start of the study. This slide summarizes the incidence of cardiovascular events in patients with normal vs impaired endothelial function during a 5-year follow-up. Patients with normal endothelial function (FMD 10%, n = 27) and patients with endothelial dysfunction (FMD 10%, n = 46) differed in their cardiovascular outcomes. Significantly more patients with endothelial dysfunction required coronary revasularization: coronary angioplasty, 7% versus 37%, P = .03; coronary bypass grafting (CABG), 0% versus 15%, P = .009. Patients with endothelial dysfunction had a 20% incidence of myocardial infarction (MI) compared with 11% in the group with normal endothelial function. The difference was not statistically significant, which the authors attributed to the low incidence of MI (12 cases) during follow-up. In forecasting all cardiac events, impaired FMD had an 86% sensitivity and a 93% negative predictive value. Endothelial dysfunction was found to be an independent predictor of cardiac events. In patients with a high pretest probability of CAD, measurements of FMD can be used to predict risk of long-term cardiac events. 可以说，通络治疗是与活血化瘀法不同的两个治疗理念，活血化瘀法主要针对血液和血流状态的病理变化，而通络治疗除了针对血液、血流状态的病理变化外，还对自管自身的病理变化具有良好的作用 * * * 正常对照组大鼠坐骨神经结构清晰，髓鞘完整，神经微丝排列整齐，神经滋养血管结构正常，管腔通畅。模型组大鼠坐骨神经有髓神经纤维形态不规则，较多的神经纤维髓鞘密度不均匀，肿胀变形，板层分离，部分髓鞘呈葱管样改变，向轴突凹陷，轴突萎缩；神经滋养血管管腔外胶质纤维轻度增生，血管内红细胞淤积。通络方剂高、低剂量治疗组神经纤维的髓鞘仍不正常，髓鞘的板层密度不均匀，仍有板层局部疏松，但较模型组明显减轻，血管内红细胞淤积现象也减轻，通络方剂高剂量治疗组的坐骨神经形态学改变要较通络方剂低剂量治疗组好。 保护内皮 一级预防 内皮功能障碍与心脑血管事件的关系及药物干预研究 以岭药业