Calium Cycling in Cardiac Cells在心肌细胞钙循环.pptVIP

Calcium Cycling in Cardiac Cells Cardiac E-C coupling Slow or L-type Ca2+ Channels (DHPRs) L-type Ca2+ Channels Ca2+ Release Channel of the Sarcoplasmic Reticulum (Ryanodine Receptor) cardiac ryanodin receptor Physiological and pathophysiological regulation Ca2+ Pump of the Sarcoplasmic Reticulum (SERCA) SERCA SERCA-PLN complex The Ca2+ Pump of the PlasmaMembrane (PMCA) Sodium/Calcium Exchanger (NCX) Troponin C (TnC) Calmodulin (CaM) Calmodulin (CaM) Calmodulin Kinase II (CaMKII) Regulation of Ca Transporters by CaM and CaMKII frequency-dependent acceleration of relaxation (FDAR) Calsequestrin (CSQ) Organization of EC coupling elements Integrative Analysis of Calcium Cycling in Cardiac Muscle Ca2+ Requirements for Activation of Myofilaments Modulation of the RyR Ca2+ Influx During the Cardiac AP Ca2+ Removal From the Cytosol DuringCardiac Relaxation Frequency-dependent changes in the fraction of Ca release that is taken back up by the SR Measurement of SR Ca2+ content and forcefrequency relationship. force frequency relation Frequency-dependence of isometric twitch force (twitch) and rapid cooling contractures (RCC) in nonfailing and failing human myocardium Relationship between NCX and SERCA protein levels and in non-failing and failing human myocardium Caffeine contractures in isolated rabbit myocytes following adenoviral gene transfer of LacZ and NCX Frequency-dependent changes in twitch force, aequorin light signals RCCs in huma atrial muscles (A) and ventricular muscles (B). Steady-state twitches, postrest twitches, and RCCs in isolated human atrial myocardium. Rapid Cooling Contracture * Lin Guo-hua Phospholamban (PLN) Sarcolipin (SLN) Calmodulin Kinase II (CaMKII) [Ca2+]i Transient in Heart Cell [Ca2+]I Transient [Ca2+]i sparks Autoregulation of SR Ca2+ Content Changes of sarcolemmal fluxes and SR CaCa2+ release during potentiation of CICR by caffeine (500 mmol/L) relationships between the various Ca2+ fluxes *