痤疮免疫及炎症反应.pptVIP

Jeremy and colleagues (Leeds, UK Cunliffe) conducted an immunohistochemical study to determine whether inflammatory events occur pre- or post-hyperproliferation of the follicular epithelium. Biopsies were taken of uninvolved skin (n=20) and early inflamed lesions (n=12) from acne patients as well as normal skin from control patients without acne (n=10), and inflammatory markers such as T cells, neutrophils, macrophages, α6-integrin, and interleukin-1 were examined and compared. Reference: Jeremy AH, Holland DB, Roberts SG, Thomson KF, Cunliffe WJ. Inflammatory events are involved in acne lesion initiation. J Invest Dermatol. 2003;121(1):20-27. Significant inflammatory factors were identified around clinically normal follicles from uninvolved skin from acne patients prior to epithelial hyperkeratinization. These findings included large numbers of CD4+ T cells over and above the constitutive level of surveillance T cells in normal skin, accompanied by a large macrophage presence equivalent to that seen in clinically apparent early (less than 6 hours) inflamed lesions. In addition, levels of IL-1 were upregulated perifollicularly in uninvolved skin, and aberrant integrin expression was observed in the epidermis around these uninvolved follicles as well as inflamed lesions. Thus, this study provides evidence for the involvement of inflammatory events in very earliest stages of acne lesion development. Reference: Jeremy AH, Holland DB, Roberts SG, Thomson KF, Cunliffe WJ. Inflammatory events are involved in acne lesion initiation. J Invest Dermatol. 2003;121(1):20-27. A 2008 study (Sewon KANG) used digital photography and spatial alignment software to investigate the evolution of inflammatory acne lesions, which have traditionally been thought to derive from comedones. Six predefined lesion types, including inflammatory lesions, were counted and tracked from photographs taken every 2 weeks for 12 weeks from 25 individuals with untreated facial acne. Inflammatory lesion