第一讲：白细胞分化抗原和黏附分子1PPT.pptx

;教学目的;;黏附 分子;第一章 白细胞分化抗原;CD;人CD分组（2010年）;人CD分组（2010年）; How many human CD numbers will be named? Human protein-coding genes: ~ 21150 Estimated human genes coding for membrane proteins: ~5500 (Appr. 26% of known human protein-coding genes) Having generated human cell membrane proteins: 3702 Estimated human leukocyte/ lymphoid tissue cell surface molecules: ~2500 Identified genes expressed on membrane on immune cells or in lymphoid tissues: 1050 Named CD cell surface molecules : 363 (~35% of known leukocyte cell surface molecules);Ig superfamily GPCR superfamily C-type lectin family Cytokine receptor family Protein kinase superfamily MHC class family Solute carrier family TNFR superfamily Integrin family Tetraspanin family ABC transporters superfamily TNF superfamily Peptidase protein family Cadherin superfamily Toll-like receptor family Sialomucin family Leucine-rich repeat family;;LDA胞膜外区结构;LDA胞浆区结构;;CD3分子;CD4分子;;CD4分子结合的配体 ;CD8分子;;CD28分子;;CTLA-4（CD152）;B7;ICOS（inducible costimulator）;CD40配体（CD40L, CD154）;;CD79a/CD79b分子;;CD19分子