il33及可溶性st2在心力衰竭中的价值和意义-the value and significance of il33 and soluble st2 in heart failure.docx

中文摘要IL-33及可溶性ST2在心力衰竭中的价值和意义期血清IL-33及sST2水平比较，差异均无统计学意义（p0.05）。（4）心功能IV级患者血清sST2水平明显高于心功能II级患者（p0.01），高于心功能III级患者（p0.017），差异均有统计学意义；不同心功能组血清IL-33水平比较，差异无统计学意义（P0.017）。（5）通过Spearman相关分析显示，IL-33水平与sST2水平不存在相关性（r=0.052,p0.05）。（6）通过Spearman相关分析显示，sST2与NT-proBNP呈正相关（r=0.241，P0.05）；与hs-CRP呈正相关（r=0.360，P0.01）；与NYHA分级呈正相关（r=0.648，P0.01）；与LVEF呈负相关（r=-0.356，P0.01）。（7）sST2诊断心衰的ROC曲线下面积为0.694（95%CI：0.571-0.817，p0.01），NT-proBNP诊断心衰的ROC曲线下面积为0.985（95%CI：0.000-1.000，p0.01）。结论：（1）心衰患者血清IL-33及sST2水平均明显升高，其中sST2水平与心衰严重程度明显相关。（2）血清sST2水平与NT-proBNP、hs-CRP呈正相关，与左室射血分数呈负相关。（3）血清sST2是诊断心衰的一种新的生物标志物，可成为心脏超声和NT-proBNP补充手段，提高对心衰的诊断价值，并能预测心衰预后。(4)IL-33/ST2L信号通路具有心脏保护作用，干预此信号通路可能成为心衰的治疗靶标。关键词：白介素-33；可溶性ST2；心力衰竭作者：丁兵指导老师：宋建平IL-33及可溶性ST2在心力衰竭中的价值和意义英文摘要TheroleofIL-33andsST2indiagnosingheartfailureAbstractObjective:ToexaminetheserumlevelsofInterleukin-33(IL-33)andsolubleST2(sST2)inpatientswithheartfailure,andfurtherexploretheapplicationvaluesandclinicalsignificanceofIL-33andsST2inheartfailure.Methods:Atotalof44patientswithheartfailureadmittedincardiovasculardepartmentinSuzhouUniversityaffiliated1stHospitalfromJuly.2013toDec.2014wereenrolled.Accordingtothepathogenthepatientsweredividedinto3groups,including14,10,20.OnthebasisofNYHAclassificationthepatientswereclassifiedinto14,13,17.Meanwhile,24healthypeoplewereenrolledascontrol,whichwereselectedfromCenterofHealthExamination.Thecardiacultrasoundtest(UCG)andplasmaNT-proBNPlevelsofpatientsweredetermined,andalloftheclinicaldatawererecorded.SerumIL-33andsST2levelswereinvestigatedinbothacutestagewhenpatientswereadmittedtohospitalandstablestageafterbeingadmittedtohospitalfor7-14daysinaverageinheartFailuregroup.SerumIL-33andsST2levelsweretestedincontrolgroup,inwhichvolunteersunderwenthealthexaminethatwereadmittedtohospital.ComparingtheserumIL-33andsST2levelsinHFgroup(acutestage,stablestage)andcontrolgroup;ComparingtheserumIL-33andsST2levelsinHFgrouparoundacutestageandstablestage.ComparingtheserumIL-33andsST2levels(acutestage,stablestage)ofpatientscausedbyd