有哪些信誉好的足球投注网站igfbp4在wntβcatenin信号通路介导的散发性大肠管 状腺瘤癌变过程中的表达及意义-expression and significance of igf bp 4 in the carcinogenesis of sporadic large intestinal tubular adenoma mediated by wnt β catenin signaling pathway.docx
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igfbp4在wntβcatenin信号通路介导的散发性大肠管 状腺瘤癌变过程中的表达及意义-expression and significance of igf bp 4 in the carcinogenesis of sporadic large intestinal tubular adenoma mediated by wnt β catenin signaling pathway
目录中文摘要············································································································1英文摘要············································································································6英文缩写·········································································································14研究论文IGFBP-4在Wnt/β-catenin信号通路介导的散发性大肠管状腺瘤癌变过程中的表达及意义前言·········································································································15材料与方法····························································································17结果·········································································································21附图·········································································································25附表·········································································································32讨论·········································································································44结论·········································································································47参考文献·········································································································48综述IGFBP-4功能及其与肿瘤的研究进展················································51致谢··················································································································63个人简历·········································································································64IGFBP-4在Wnt/β-catenin信号通路介导的散发性大肠管状腺瘤癌变过程中的表达及意义摘要目的：大肠腺瘤是最常见的消化道良性病变，发病率较高，管状腺瘤是大肠腺瘤最常见的组织学类型，属于大肠癌的主要癌前病变，临床上散发性管状腺瘤癌变并不少见，但其形成及癌变机制错综复杂，目前尚不明确，且缺少系统性研究工作，探索前景广泛。本课题组近二十余年一直致力于散发性大肠管状腺瘤以及腺瘤癌变发生发展机制的研究；尤其是Wnt/β-catenin信号通路在散发性大肠管状腺瘤癌变过程中作用及机制的研究，前期研究发现RUNX3、HMGA2等因子可能通过调控Wnt/β-catenin信号通路而参与大肠管状腺瘤癌变的发生发展，其作用机制十分复杂。目前有研究报道，胰岛素样生长因子结合蛋白4（IGFBP-4）在细胞发育进程中可以与Wnt/β-catenin信号通路中Wnt受体Frizzled8竞争性结合，从而使Wnt通路失活，抑制细胞的分化。但是在散发性大肠管状腺瘤癌变过程中，IGFBP-4是否也通过
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