玫瑰糠疹教课书MicrosoftWord文档.docVIP

玫瑰糠疹Pityriasis rosea 玫瑰糠疹（pityriasis rosea)为一种轻度炎症性发疹性皮肤病，典型皮损为覆有领圈状糠状鳞屑的玫瑰色斑疹，病程为自限性。 Pityriasis rosea (pityriasis rosea) is a mild rash of inflammatory skin disease. Its typical skin lesion is the rose-like rash covered with collar- bran-like scales , and its disease duration is self-limiting. [病因和发病机制] 病因不明，研究提示可能免疫/自身免疫、变态反应、遗传易感性等有关。已经证实的有：皮损内浸润的细胞主要为辅助/诱导T淋巴细胞；表皮、真皮乳头内朗格汉斯细胞明显增多；角质形成细胞出现HLA-DR抗原的表达等。[Etiology and pathogenesis] Cause is unknown, research suggests that may be about immune / autoimmune, allergic, genetic susceptibility and so on. Factors below have been confirmed : infiltration of cells within the lesions are mainly helper / induced T lymphocytes;,Langerhans cells increase in epidermis and dermal papilla obviously; the expression of HLA-DR antigen appears frome keratinocytes and so on. [临床表现] 发病率1.09~4.80%，中青年多见，春秋季多发，发疹前部分患者有上感/上感样症状，好发于躯干与四肢的近段，初起皮损为孤立的玫瑰色淡红斑，直径可迅速扩大至2~５cm，覆有细薄的鳞屑，称为前驱斑或为母斑（mother patch）1~2周内逐渐出现大小不等的红色斑片（继发斑），状同母斑，直径0.2~1cm，称为子斑，常呈椭圆形，表面有稀薄鳞屑，其长轴与皮纹走行一致，表面有细小的皮纹加深皱纹或见稀薄的糠秕样磷屑并向内游离。色：淡红色、黄红色（玫瑰色）。也可变为红色或暗红色。常伴有不同程度的痒感，部分患者出汗/洗澡，可使病情加重。本病有自限性，病程一般为4~8周。也有数月数年不愈者，愈后一般不复发。[Clinical] incidence of 1.09 to 4.80%, middle-aged more common in spring and fall-prone, rash in some patients with the flu before / the flu-like symptoms, occur in the trunk and proximal limbs, early lesions with isolated The rosy light erythema, the diameter can be quickly expanded to 2 ~ 5cm, covered with small thin scales, known as the precursor spot or nevus (mother patch), also the mother of 2 or 3 spots, 1 to 2 weeks gradual emergence of the red patches of varying sizes (secondary spot), like with nevus diameter of 0.2 ~ 1cm, known as the sub-spot, often has an oval, the surface of thin scales, walking sticks its long axis with the same line, the surface there is a small striae deeper wrinkles or see the thin chip to the chaff-like phosphate free. Color: light red, yellow red (rose). Can also become red or dark red. Often accompanied by varying degrees o