荭草素-2-o-β-d-半乳糖苷抑制小胶质细胞炎症反应及其机制研究word格式论文.docxVIP

优秀毕业论文 精品参考文献资料 目 录  HYPERLINK \l _bookmark0 目 录 ··························································································· 3  HYPERLINK \l _bookmark1 前 言 ··························································································· 1  HYPERLINK \l _bookmark2 材料与方法 ······················································································· 3  HYPERLINK \l _bookmark3 实验材料····················································································· 3  HYPERLINK \l _bookmark4 实验方法····················································································· 4  HYPERLINK \l _bookmark5 结 果 ··························································································12  HYPERLINK \l _bookmark6 讨 论 ··························································································24  HYPERLINK \l _bookmark7 结 论 ··························································································27  HYPERLINK \l _bookmark8 参考文献 ·························································································28  HYPERLINK \l _bookmark9 综 述 ····························································································33  HYPERLINK \l _bookmark77 缩写词表 ···············??·········································································43  HYPERLINK \l _bookmark78 致 谢 ··························································································44 荭草素-2-O-β-D-半乳糖苷抑制小胶质细胞炎症反应及其机制研究 前言  PAGE 2  PAGE 1 前 言 神经退行性疾病(Neurodegenerative disease)是一类以大脑和脊髓的神经元细胞 丧 失 为 特 征 的 疾 病 ， 如 阿 尔 茨 海 默 病 （ Alzheimer disease ， AD ）， 帕 金 森 病 （Parkinson’s disease，PD），多发性硬化症（Multiple Sclerosis，MS）等。目前对 于神经退行性疾病的病因和发病机制尚未完全研究清楚，遗传因素，环境因素， 氧化应激反应，线粒体功能障碍等假说被认为与其发病有着密切的联系。越来越 多的研究表明神经炎症参与神经退行性疾病的发生和发展过程 HYPERLINK \l _bookmark10 [1]。McGeer 等报道 在 PD 病人脑内黑质纹状体中存有大量激活的小胶质细胞，并且相关炎症因子如肿 瘤坏死因子-α（TNF-α），白介素-1β（IL-1β）等均有高表达 HYPERLINK \l _bookm