antihbec和aca与慢性阻塞性肺疾病的相关性研究word格式论文.docxVIP

摘要 ······················································································ IAbstract ················································································ Ⅲ 缩略词表 ·············································································· Ⅵ 前言 1第一章 慢性阻塞性肺疾病中 IgG、IgA 和 IgM 型抗支气管上皮细胞抗体1 前言 42 实验材料和方法 ··································································43 结果 ··············································································· 114 讨论 ··············································································· 155 结论 ··············································································· 16 第二章 慢性阻塞性肺疾病中抗心磷脂抗体水平分析 ······················· 18 1 前言 ··············································································· 182 实验材料和方法 ································································ 183 结果 ··············································································· 234 讨论 ··············································································· 245 结论 ··············································································· 25结语 ···················································································· 27参考文献 ·············································································· 28综述 ···················································································· 30攻读硕士期间发表论文情况 ······················································ 50致谢 ···················································································· 51第一章：慢性阻塞性肺疾病中 IgG、IgA 和 IgM 型抗支气管上皮细胞抗体背景: 近年来，越来越多的研究表明，自身免疫和支气管上皮细胞受损在 慢性阻塞性肺疾病（COPD）的发病机制中起重要作用。循环的抗支气管 上皮细胞抗体（anti-HBEC）结合到 COPD 患者的支气管上皮细胞上，可 引起支气管上皮细胞的损伤。因此，本文旨在探讨 COPD 患者血清中 IgA、 IgG 和 IgM 型 anti-HBEC 与 COPD 临床特点的关系。方法: 用间接免疫荧光的方法对 170 例 COPD 患者和 150 例健康对照组血 清进行 IgA、IgG 和 IgM 型 anti-HBEC 的检测，分析该抗体阳性与 COPD 患者的肺功能、BMI、性别和年龄等的关系。结果: COPD 中 IgG 型 anti-HBEC 阳性率明显高于健康对照组（20.00% vs 7.33%，1:100 稀释）（P 0.05）；IgA 型 anti-HBEC 阳性率也显著高于 健康对照组（