卡铂-PLGA缓释微球局部化疗对VX2兔肝肿瘤术后复发的影....pdfVIP

卡铂-PLGA 缓释微球局部化疗对 VX 兔肝肿瘤术后复发的影响 2 1，2 1 李京京 ,卓忠雄 (1.第三军医大学附属新桥医院超声诊断科,重庆 400037； 2.武警江苏总队医院南京分院影像科 江苏南京 210028 ) 摘 要 目的 探讨肝癌切除术后卡铂-PLGA缓释微球局部化疗对其复发的影响。方法:把30只VX2荷瘤兔，随机 化原则分为3组，每组10只。A组：卡铂缓释微球放置组；B组：卡铂原药放置组；C组：卡铂原药静脉注射组。A、 B组行手术切除，并与瘤腔置药；C组手术切除后耳缘静脉注射，治疗后观察肿瘤复发率、存活率、肝功能变化 情况等。结果: 第10、21d肿瘤复发率：A组为40%、80% ；B 组为60 %、100 %；C组为70 %、100%。平均存活时 间：A组为53.2 ±2.5；B组为45.5 ±3.7；C组为43.2 ±4.5。A组与B、C组相比，差异有显著统计学意义。结论: 肝癌术后放置卡铂缓释微球能降低复发率,延长生存时间。 关键词 原发性肝癌；手术切除；化疗；复发 Preventive effects on recurrence of VX2 liver cancer by local chemotherapy with carboplatin –PLGA microspheres after hepalectomy LI Jing-jing, ZHUO Zhong-xiong (Department of Ultrasound , Xinqiao Hospital , Third Military Medical University , Chongqing 400037 , China;Department of general image, Nanjing Hospital of Armed Police Force,Nanjing 210028,Jiangsu,China) Abstract Objective To study the effects of carboplatin-PLGA microspheres of chemotherapy on recurrence of VX2 liver cancer after hepalectomy. Methods: 30 of VX2 tumor-bearing rabbits were randomly divided into three groups and ten rats per group were used. Group A, carboplatin release microspheres placed; Group B: original carboplatin agent placed; Group C: original carboplatin intravenous injection. Group A and B were treated with surgical resection, and tumor cavity was placed agents; Group C were performed with surgical resection and ears margin intravenous injection were used. After treatment, the tumor recurrence rate, survival rate and the changes in liver function were investigated. Results: The 10 and 21-days tumor recurre