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regulation of xbp-1 signaling during transient and stable recombinant protein production in cho cells文档.pdf

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regulation of xbp-1 signaling during transient and stable recombinant protein production in cho cells文档

Regulation of XBP-1 Signaling During Transient and Stable Recombinant Protein Production in CHO Cells Sebastian C. Y. Ku Expression Engineering Group, Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), Singapore 138668, Singapore NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 119220, Singapore Poh Choo Toh, Yih Yean Lee, and Janet Chusainow Animal Cell Technology Group, Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), Singapore 138668, Singapore Miranda G. S. Yap Animal Cell Technology Group, Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), Singapore 138668, Singapore NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 119220, Singapore Dept. of Chemical Biomolecular Engineering, National University of Singapore, Singapore 119220, Singapore Sheng-Hao Chao Expression Engineering Group, Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), Singapore 138668, Singapore DOI 10.1002/btpr.322 Published online November 24, 2009 in Wiley InterScience (). X-box binding protein 1 (XBP-1) is a key regulator of cellular unfolded protein response (UPR). The spliced isoform of XBP-1, XBP-1S, is a transcription activator, which is expressed only when UPR is induced. However, the impact of recombinant protein produc- tion on the regulation of XBP-1 signaling in CHO cells is not well understood. In this report, we cloned the Chinese hamster XBP-1 homolog to aid the investigation of the inter- play between protein productivity, culture conditions, and endogenous XBP-1 signaling in