proton-detected solid-state nmr spectroscopy of bone with ultrafast magic angle spinning:用超快魔角纺丝技术检测骨的固态核磁共振光谱.pdfVIP
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proton-detected solid-state nmr spectroscopy of bone with ultrafast magic angle spinning:用超快魔角纺丝技术检测骨的固态核磁共振光谱
/scientificreports OPEN Proton-Detected Solid-State NMR Spectroscopy of Bone with Ultrafast Magic Angle Spinning Received: 24 March 2015 1,2 3,4 4 2 5 Accepted: 05 May 2015 Kamal H. Mroue , Yusuke Nishiyama , Manoj Kumar Pandey , Bo Gong , Erin McNerny , 5 2 1,2 David H. Kohn , Michael D. Morris Ayyalusamy Ramamoorthy Published: 08 July 2015 While obtaining high-resolution structural details from bone is highly important to better understand its mechanical strength and the effects of aging and disease on bone ultrastructure, it has been a major challenge to do so with existing biophysical techniques. Though solid-state NMR spectroscopy has the potential to reveal the structural details of bone, it suffers from poor spectral resolution and sensitivity. Nonetheless, recent developments in magic angle spinning (MAS) NMR technology have made it possible to spin solid samples up to 110 kHz frequency. With such remarkable capabilities, 1 H-detected NMR experiments that have traditionally been challenging on rigid solids can now be implemented. Here, we report the first application of multidimensional 1 H-detected NMR
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